Regulation of inositol lipid kinases by Rho and Rac
Regulation of inositol lipid kinases by Rho and Rac
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DOI：
10.1016/s0959-437x(98)80063-4
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发表时间：
1998-02-01
影响因子：
4
通讯作者：
Schwartz, MA
中科院分区：
文献类型：
--
作者：
Ren, XD;Schwartz, MA
Rho和Rac小GTP酶与I型磷脂酰肌醇4-磷酸5-激酶结合以调节磷脂酰肌醇4，5-二磷酸的产生。这种脂质似乎介导了Rho和Rac对肌动蛋白细胞骨架的一些影响。最近已经克隆了几种I型磷脂酰肌醇4-磷酸5-激酶的基因，但不知道哪一种与Rho和/或Rac相互作用。Rho家族GTP酶也与磷脂酰肌醇8-激酶相互作用，尽管该激酶可以是GTP酶的上游或下游，这取决于系统。
Rho and Rac small GTPases associate with type-I phosphatidylinositol 4-phosphate 5-kinase to regulate the production of phosphatidylinositol 4,5-bisphosphate. This lipid appears to mediate some of the effects of Rho and Rac on the actin cytoskeleton. The genes for several type-I phosphatidylinositol 4-phosphate 5-kinases have been cloned recently but it is not known which one interacts with Rho and/or Rac. Rho family GTPases also interact with phosphatidylinositol 8-kinase, though this kinase can be either upstream or downstream of the GTPases depending upon the system.