An Injectable, biodegradable magnetic hydrogel system for exogenous promotion of muscle mass and regeneration
An Injectable, biodegradable magnetic hydrogel system for exogenous promotion of muscle mass and regeneration
复制标题
一种可注射、可生物降解的磁性水凝胶系统，用于外源性促进肌肉质量和再生
DOI：
10.1016/j.cej.2021.130398
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发表时间：
2021-05-31
影响因子：
15.1
通讯作者：
Xu，Feng
中科院分区：
文献类型：
--
作者：
Chang，Le;Li，Yuhui;Xu，Feng
损伤后的肌肉萎缩可以通过按摩治疗或通过周期性驱动的模拟按摩的磁水凝胶植入物来缓解。尽管众所周知，在运动训练和机械生物学中，平行于肌肉收缩轴的收缩在促进肌肉强化方面优于这种侧向压缩，但尚不清楚这是否适用于防止肌肉废用性萎缩。为了验证轴向拉伸可以缓解肌肉废用性萎缩的假设，我们开发了一种可注射的、可生物降解的磁性水凝胶系统，通过周期性的轴向肌肉拉伸外源性促进肌肉质量和再生，并在废用性萎缩的动物模型中对该系统进行了测试。该系统由一个生物相容的磁性水凝胶组成，可以注射到肌肉中，并通过可穿戴设备驱动周期性拉伸肌肉。这种水凝胶具有耐用性和自我修复性，当触发降解时，它会在两周内从体内排出。结果显示，在动物模型中，轴向肌拉伸在维持肌肉质量和结构方面优于按摩样压缩，并提示了在长时间卧床休息、持续昏迷和长时间太空飞行期间对抗肌肉废用性萎缩的途径。
Muscle atrophy following injury can be alleviated by periodic, lateral muscle compression via massage therapy or via periodically actuated magnetically hydrogel implants that simulate massage. Although contraction parallel to a muscle’s contractile axis is well known to be superior to such lateral compression for promoting muscle strengthening in both athletic training and mechanobiology, it is not known whether this is the case for preventing muscle disuse atrophy. To test the hypothesis that axial stretch can alleviate muscle disuse atrophy, we therefore developed an injectable, biodegradable magnetic hydrogel system for exogenous promotion of muscle mass and regeneration through periodic, axial muscle stretch, and tested the system in an animal model of disuse atrophy. The system consists of a biocompatible magnetic hydrogel that can be injected into muscles and actuated to stretch muscles periodically by a wearable device. The hydrogel is durable and self-healing, and when triggered to degrade is flushed from the body over the course of two weeks. Results showed axial muscle stretch to be superior to massage-like compression in maintaining muscle mass and structure in the animal model, and suggests pathways for combatting muscle disuse atrophy during prolonged bed rest, persistent coma, and prolonged spaceflight.