CROHNS-DISEASE - TRANSMISSION ELECTRON-MICROSCOPIC STUDIES .3. TARGET TISSUES - PROLIFERATION OF AND INJURY TO SMOOTH-MUSCLE AND THE AUTONOMIC NERVOUS-SYSTEM
CROHNS-DISEASE - TRANSMISSION ELECTRON-MICROSCOPIC STUDIES .3. TARGET TISSUES - PROLIFERATION OF AND INJURY TO SMOOTH-MUSCLE AND THE AUTONOMIC NERVOUS-SYSTEM
复制标题
DOI：
10.1016/s0046-8177(80)80073-6
复制
发表时间：
1980-01-01
期刊：
影响因子：
3.3
通讯作者：
DICKERSIN, GR
中科院分区：
文献类型：
--
作者：
DVORAK, AM;OSAGE, JE;DICKERSIN, GR
对12例克罗恩病患者和3例对照组的手术标本进行透射电子显微镜检查。选择回肠的非溃疡受累区域以及近端、大体上未受累的切除边缘进行研究。透射电子显微镜标本制备的各种技术，和112块进行了EM检查。研究了肠道的两个靶组织：自主神经系统和平滑肌。每种细胞均出现增生性和损伤性变化。增生、肌纤维母细胞转化、过度收缩和坏死是回肠克罗恩病中平滑肌变化的特征。自主神经系统变化包括含有致密核心颗粒（儿茶酚胺）的轴突增殖和轴突坏死。这些变化可能的发病意义进行了讨论。
Transmission electron microscopy was done on surgical specimens from 12 patients with Crohn''s disease and 3 control subjects. Nonulcerated involved areas of ileum as well as proximal, grossly uninvolved resection margins were chosen for study. Specimens for transmission electron microscopy were prepared by a variety of techniques, and 112 blocks were examined by EM. Two target tissues of the gut: the autonomic nervous system and the smooth muscle were studied. Proliferative and injurious changes were found in each. Proliferation, myofibroblastic transformation, hypercontraction and necrosis characterized the smooth muscle changes seen in Crohn''s disease of the ileum. Autonomic nervous system changes included proliferation of axons containing dense core granules (catecholamines) and axonal necrosis. The possible pathogenetic significance of these changes is discussed.