Cognitive therapy versus fluoxetine in generalized social phobia: A randomized placebo-controlled trial
Cognitive therapy versus fluoxetine in generalized social phobia: A randomized placebo-controlled trial
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DOI：
10.1037/0022-006x.71.6.1058
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发表时间：
2003-12-01
影响因子：
5.9
通讯作者：
Louis, B
中科院分区：
文献类型：
--
作者：
Clark, DM;Ehlers, A;Louis, B
60名符合精神障碍诊断和统计手册（第4版）的患者;美国精神病学协会，1994）的标准，广泛的社交恐怖症被分配到认知治疗（CT），氟西汀加自我暴露（FLU + SE），或安慰剂加自我暴露（PLA + SE）。在治疗后（16周），药物盲态被打破。CT和FLU + SE患者随后进入3个月的加强阶段。在治疗前进行评估。治疗中期、治疗后、加强阶段结束和12个月随访。在所有3种治疗中，观察到大多数指标均显著改善。在社交恐怖方面，治疗中、后CT组上级优于FLU + SE组和PLA + SE组。FLU + SE和PLA + SE无差异。在加强阶段结束时和12个月随访时，CT仍上级优于FLU + SE。在一般情绪测量方面，治疗组之间几乎没有差异。
Sixty patients meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed.; American Psychiatric Association, 1994) criteria for generalized social phobia were assigned to cognitive therapy (CT), fluoxetine plus self-exposure (FLU + SE), or placebo plus self-exposure (PLA + SE). At posttreatment (16 weeks), the medication blind was broken. CT and FLU + SE patients then entered a 3-month booster phase. Assessments were at pretreatment. midtreatment, posttreatment, end of booster phase, and 12-month follow-up. Significant improvements were observed on most measures in all 3 treatments. On measures of social phobia, CT was superior to FLU + SE and PLA + SE at midtreatment and at posttreatment. FLU + SE and PLA + SE did not differ. CT remained superior to FLU + SE at the end of the booster period and at 12-month follow-up. On general mood measures, there were few differences between the treatments.