The Impact of Marijuana Use on the Successful Aging of HIV-Infected Adults.
The Impact of Marijuana Use on the Successful Aging of HIV-Infected Adults.
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DOI：
10.1097/qai.0000000000000562
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发表时间：
2015-06-01
期刊：
影响因子：
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通讯作者：
Erlandson KM
中科院分区：
文献类型：
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作者：
Allshouse AA;MaWhinney S;Jankowski CM;Kohrt WM;Campbell TB;Erlandson KM
确定自我报告的大麻使用对人类免疫缺陷病毒感染者成功衰老的影响。对 45 至 65 岁 HIV 感染者进行的横断面研究，这些受试者接受抗逆转录病毒治疗超过 6 个月，且 HIV-1 病毒载量检测不到。成功的衰老被定义为没有疾病；足够的身体机能；高生活质量 (QOL) 和社会参与度。使用逻辑回归或线性回归进行二元或连续测量，对由自我报告的近期大麻使用 (RMU) 定义的各组之间的临床特征、身体功能评估和简表 36 (SF-36) 的生活质量进行比较，并根据烟草使用、CD4+ T 细胞计数和自 HIV 诊断后的时间进行调整。 359 名受试者中有 93 名 (26%) 报告了 RMU。从人口统计学上看，报告 RMU 的患者最近被诊断出 HIV 的时间较晚（14 [13-16] vs 11 [10-12] 岁），报告吸烟（48% vs 25%）且收入较低（92% vs 80%），且患病率高于非 RMU 患者；其他人口统计和临床特征（年龄、CD4+ T 细胞计数）相似。性别、种族/民族、身体状况、身体功能和疾病负担没有显着差异。与未使用 RMU 的患者相比，报告 RMU 的患者表现出较低的心理生活质量、低社会参与度以及失业或就业不足的可能性增加。在评估报告 RMU 老龄化的 HIV 患者的成功程度时，应考虑 RMU 与心理或社会生活质量之间的负相关关系。
To determine the impact of self-reported marijuana use on the components of successful aging of human immunodeficiency virus-infected persons. Cross-sectional study of 45- to 65-year-old HIV-infected subjects on anti-retroviral therapy >6 months with undetectable HIV-1 viral load. Successful aging was defined as absence of disease; adequate physical function; high Quality of Life (QOL) and social engagement. Clinical characteristics, physical function assessments, and QOL from short-form 36 (SF-36) were compared between groups defined by self-reported Recent Marijuana Use (RMU), adjusted for tobacco use, CD4+ T-cell count and time since HIV diagnosis, using logistic or linear regression for binary or continuous measures. 93 of 359 total subjects (26%) reported RMU. Demographically, patients reporting RMU had been diagnosed with HIV less recently (14 [13–16] vs 11 [10–12] years), reported smoking (48% vs 25%) and lower income (92% vs 80%) with greater prevalence than non-RMU patients; other demographics and clinical characteristics (age, CD4+ T-cell count) were similar. Gender, race/ethnicity, physical outcomes, physical function and disease burden were not significantly different. Patients reporting RMU demonstrated lower mental QOL and increased odds of low social engagement and un- or underemployment compared to non-users. The negative association between RMU and mental or social QOL should be considered when assessing the success with which HIV patients reporting RMU are aging.