Tanycytes and a Differential Fatty Acid Metabolism in the Hypothalamus
Tanycytes and a Differential Fatty Acid Metabolism in the Hypothalamus
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DOI：
10.1002/glia.23088
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发表时间：
2017-02-01
期刊：
影响因子：
6.2
通讯作者：
Kuerschner, Lars
中科院分区：
文献类型：
--
作者：
Hofmann, Kristina;Lamberz, Christian;Kuerschner, Lars
虽然大脑控制着整个生物体的所有主要代谢途径，但它的脂质代谢与身体的其他部分部分是分开的。循环脂质和其他代谢物被吸收到大脑区域，如下丘脑，并被局部代谢和感知，涉及几种下丘脑细胞类型。在这项研究中，我们表明，饱和和不饱和脂肪酸的差异处理在小鼠下丘脑。观察到的差异涉及脂质分布和代谢。主要调查结果如下：（i）在瘦小鼠中，下丘脑星形胶质细胞被不饱和而非饱和脂质靶向;（ii）在肥胖小鼠中，除非氧化或生酮被抑制，否则不能检测到这些星形胶质细胞被不饱和油酸标记;（iii）肥胖动物的下丘脑增加酮体和中性脂质合成，而伸长细胞（面向心室的下丘脑细胞）增加其脂滴含量;和（iv）伸长细胞显示饱和或不饱和脂质的不同标记。我们的数据支持伸长细胞和星形胶质细胞之间的代谢联系可能会影响下丘脑脂质传感。
Although the brain controls all main metabolic pathways in the whole organism, its lipid metabolism is partially separated from the rest of the body. Circulating lipids and other metabolites are taken up into brain areas like the hypothalamus and are locally metabolized and sensed involving several hypothalamic cell types. In this study we show that saturated and unsaturated fatty acids are differentially processed in the murine hypothalamus. The observed differences involve both lipid distribution and metabolism. Key findings were: (i) hypothalamic astrocytes are targeted by unsaturated, but not saturated lipids in lean mice; (ii) in obese mice labeling of these astrocytes by unsaturated oleic acid cannot be detected unless -oxidation or ketogenesis is inhibited; (iii) the hypothalamus of obese animals increases ketone body and neutral lipid synthesis while tanycytes, hypothalamic cells facing the ventricle, increase their lipid droplet content; and (iv) tanycytes show different labeling for saturated or unsaturated lipids. Our data support a metabolic connection between tanycytes and astrocytes likely to impact hypothalamic lipid sensing.