Near-Infrared Light-Responsive Intracellular Drug and siRNA Release Using Au Nanoensembles with Oligonucleotide-Capped Silica Shell
Near-Infrared Light-Responsive Intracellular Drug and siRNA Release Using Au Nanoensembles with Oligonucleotide-Capped Silica Shell
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DOI：
10.1002/adma.201200785
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发表时间：
2012-07-03
影响因子：
29.4
通讯作者：
Yeh, Chen-Sheng
中科院分区：
文献类型：
--
作者：
Chang, Yi-Ting;Liao, Pei-Yi;Yeh, Chen-Sheng
利用金纳米棒吸收近红外光的特性，开发了一种近红外响应型寡核苷酸门控集成来实现细胞内药物传递。使用寡核苷酸生物门使siRNA能够释放到细胞中进行翻译调节，并在抗癌药物传递中发挥细胞毒性。
Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery.