Food patterns, inflammation markers and incidence of cardiovascular disease: the Malmo Diet and Cancer study
Food patterns, inflammation markers and incidence of cardiovascular disease: the Malmo Diet and Cancer study
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DOI：
10.1111/j.1365-2796.2011.02382.x
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发表时间：
2011-10-01
影响因子：
11.1
通讯作者：
Wirfalt, E.
中科院分区：
文献类型：
--
作者：
Hlebowicz, J.;Persson, M.;Wirfalt, E.
目标.通过13年的随访，研究使用聚类分析构建的食物模式与全身和血管炎症标志物和心血管疾病（CVD）事件之间的关联。以人群为基础的前瞻性队列研究。聚类分析确定了6种食物模式，从43个食物组变量4999名受试者，年龄在45-68岁，谁参加了马尔莫饮食和癌症心血管计划1991年至1994年。使用基线时的血液样本测量脂蛋白相关磷脂酶A（2）（Lp-PLA（2））、C反应蛋白浓度和白色血细胞（WBC）计数。CVD（冠状动脉事件和缺血性卒中）的发生率在13年的随访中被监测。富含纤维的面包模式与女性WBC计数的有利影响相关，低脂高纤维模式与女性Lp-PLA（2）质量和男性Lp-PLA（2）活性的有利影响相关。然而，牛奶脂肪和糖果和蛋糕模式都与不良反应有关;前者对女性WBC计数和男性Lp-PLA（2）质量，后者对女性WBC计数和Lp-PLA（2）质量。牛奶脂肪和糖果和蛋糕模式与女性心血管疾病风险增加有关。这项研究的结果支持目前的北欧饮食建议，即富含高纤维，低脂和低糖食物的饮食与炎症标志物以及潜在的CVD风险有利相关。
Objectives. To examine the associations between food patterns constructed using cluster analysis and markers of systemic and vascular inflammation, and incident cardiovascular disease (CVD) after 13 years of follow-up.Design. Population-based, prospective cohort study.Setting and subjects. Cluster analysis identified six food patterns from 43 food group variables among 4999 subjects, aged 45-68 years, who participated in the Malmo Diet and Cancer cardiovascular programme between 1991 and 1994. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), C-reactive protein concentration and white blood cell (WBC) count were measured using blood samples at baseline. Incidence of CVD (coronary events and ischaemic stroke) was monitored over 13 years of follow-up.Results. The fibre-rich bread pattern was associated with favourable effects on WBC count in women, and the low-fat and high-fibre pattern with favourable effects on Lp-PLA(2) mass in women, and on Lp-PLA(2) activity in men. However, the milk fat and sweets and cakes patterns were both associated with adverse effects; the former on WBC count in women and on Lp-PLA(2) mass in men, and the latter on WBC count and Lp-PLA(2) mass in women. The milk fat and sweets and cakes patterns were associated with increased CVD risk in women.Conclusions. The results of this study support the present Nordic dietary recommendations indicating that diets rich in high-fibre, low-fat and low-sugar foods are favourably associated with markers of inflammation and, potentially, with CVD risk.