Synthesis of poly(L-lactide) and polyglycolide by ring-opening polymerization
Synthesis of poly(L-lactide) and polyglycolide by ring-opening polymerization
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DOI：
10.1038/nprot.2007.391
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发表时间：
2007-01-01
期刊：
影响因子：
14.8
通讯作者：
Fisher, John P.
中科院分区：
文献类型：
--
作者：
Kaihara, Sachiko;Matsumura, Shuichi;Fisher, John P.
该方案描述了使用2-乙基己酸锡（II）催化剂通过L-丙交酯的开环聚合合成聚（L-丙交酯）以及通过乙交酯的开环聚合合成聚乙交酯。由α-羟基羧酸合成的环状双酯的开环聚合以高产率得到高分子量聚酯。2-乙基己酸锡（II）催化剂是双酯开环聚合最常用的催化剂，由于其高反应活性和低毒性。单体纯度、反应体系中水和醇的用量是提高聚酯分子量和转化率的重要因素。聚酯的分子量还取决于反应温度和反应时间。该方法可在3d内完成聚L-丙交酯的合成，在2d内完成聚乙交酯的合成。
This protocol describes the synthesis of poly(L-lactide) by ring-opening polymerization of L-lactide using tin(II) 2-ethylhexanoate catalyst as well as the synthesis of polyglycolide by ring-opening polymerization of glycolide. Ring-opening polymerization of cyclic diesters synthesized from alpha-hydroxycarboxylic acids gives high-molecular-weight polyester in high yield. Tin(II) 2-ethylhexanoate catalyst is the most common catalyst for ring-opening polymerization of diesters owing to its high reactivity and low toxicity. Purity of monomers and the amount of water and alcohol in the reaction system are significant factors for increasing molecular weight and conversion of polyesters. The molecular weight of the polyesters is also dependent on reaction temperature and reaction time. This protocol can be completed in 3 d for the synthesis of poly(L-lactide) and 2 d for the synthesis of polyglycolide.