Stimulation of the subthalamic nucleus at an earlier disease stage of Parkinson's disease: Concept and standards of the EARLYSTIM-study
Stimulation of the subthalamic nucleus at an earlier disease stage of Parkinson's disease: Concept and standards of the EARLYSTIM-study
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DOI：
10.1016/j.parkreldis.2012.07.004
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发表时间：
2013-01-01
影响因子：
4.1
通讯作者：
Schade-Brittinger, Carmen
中科院分区：
文献类型：
--
作者：
Deuschl, Guenther;Schuepbach, Michael;Schade-Brittinger, Carmen
丘脑底核（DBS）的脑深部电刺激（DBS）是一种治疗晚期帕金森病（PD）伴致残性运动并发症的既定治疗方法。然而，刺激可能是有益的，在早期阶段的PD时，运动波动和运动障碍只是轻微的和心理社会能力仍然保持。EARLYSTIM试验在近期发生左旋多巴诱导的运动并发症的患者中进行（
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for advanced Parkinson's disease (PD) with disabling motor complications. However, stimulation may be beneficial at an earlier stage of PD when motor fluctuations and dyskinesia are only mild and psychosocial competence is still maintained. The EARLYSTIM trial was conducted in patients with recent onset of levodopa-induced motor complications (