Imaging biomarkers of angiogenesis and the microvascular environment in cerebral tumours
Imaging biomarkers of angiogenesis and the microvascular environment in cerebral tumours
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DOI：
10.1259/bjr/66316279
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发表时间：
2011-12-01
影响因子：
2.6
通讯作者：
Jackson, A.
中科院分区：
文献类型：
--
作者：
Thompson, G.;Mills, S. J.;Jackson, A.
传统的对比增强CT和MRI现在在临床上常规用于脑部疾病的诊断、治疗和监测。对比增强的存在是在正常高度调节的脑血管系统和血脑屏障中发生的病理变化的代表。随着对这些技术局限性的认识，以及对各种病理过程中微血管变化的细微机制的更高认识，正在研究新技术在进一步询问大脑微血管中的效用。这在肿瘤中尤其重要，其中依赖于血管生成（新血管形成）对于肿瘤生长至关重要，并且由此产生的微血管构型和紊乱对于诊断、治疗和监测具有深远的意义。此外，寻求直接改变微血管的新治疗方法需要基线肿瘤行为和反应的更敏感和特异性的生物标志物。本文综述了目前用于血管生成和脑肿瘤微血管环境的影像学标记物。
Conventional contrast-enhanced CT and MRI are now in routine clinical use for the diagnosis, treatment and monitoring of diseases in the brain. The presence of contrast enhancement is a proxy for the pathological changes that occur in the normally highly regulated brain vasculature and blood-brain barrier. With recognition of the limitations of these techniques, and a greater appreciation for the nuanced mechanisms of microvascular change in a variety of pathological processes, novel techniques are under investigation for their utility in further interrogating the microvasculature of the brain. This is particularly important in tumours, where the reliance on angiogenesis (new vessel formation) is crucial for tumour growth, and the resulting microvascular configuration and derangement has profound implications for diagnosis, treatment and monitoring. In addition, novel therapeutic approaches that seek to directly modify the microvasculature require more sensitive and specific biological markers of baseline tumour behaviour and response. The currently used imaging biomarkers of angiogenesis and brain tumour microvascular environment are reviewed.