Relationships between rest-activity rhythms, sleep, and clinical symptoms in individuals at clinical high risk for psychosis and healthy comparison subjects.
Relationships between rest-activity rhythms, sleep, and clinical symptoms in individuals at clinical high risk for psychosis and healthy comparison subjects.
复制标题
精神病临床高风险个体和健康对照受试者的休息-活动节律、睡眠和临床症状之间的关系。
DOI：
10.1016/j.jpsychires.2022.09.009
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发表时间：
2022
影响因子：
4.8
通讯作者：
Ferrarelli,Fabio
中科院分区：
文献类型：
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作者：
LaGoy,AliceD;Mayeli,Ahmad;Smagula,StephenF;Ferrarelli,Fabio
精神病临床高危（CHR）个体的睡眠-觉醒障碍可能与症状严重程度增加有关，并有助于疾病进展。在这里，我们检查了12名CHR和16名健康对照（HC）个体之间的静息-活动节律（RAR）测量（来自活动描画）和客观睡眠结果（来自脑电图（EEG））的差异。此外，我们研究了RAR障碍、客观睡眠结果和临床精神病症状（即阴性、阳性、紊乱、一般症状）之间的关系。通过活动记录仪监测3-7天的睡眠-觉醒行为（CHR: 5.7±1.7天；HC: 6.3±1.2天），然后在睡眠实验室过夜，用脑电图监测。在控制年龄和性别后，使用单独的回归来检验临床组对RAR测量和客观睡眠结果的影响。与HC相比，CHR参与者活动较少，特别是在晚上（17:00-20:00;β = 1.145, SE = 0.362,p= 0.004）和夜间（21:00-24:00;β = 1.152, SE = 0.326,p= 0.002）。此外，CHR参与者有更多的碎片化睡眠（睡眠开始后醒来：β = 0.888, SE = 0.395,p= 0.034）和更多的睡眠过度觉醒（NREM伽马活动：β = 1.087, SE = 0.348,p= 0.005），但这些睡眠障碍与活动减少或临床症状无关，而夜间活动减少与更多的混乱症状相关（ρ =−）。640年,p = .025)。因此，通过行为干预增加活动可能对CHR临床症状有额外的有益影响。
Sleep-wake disturbances in individuals at clinical high risk (CHR) of psychosis may relate to increased symptom severity and contribute to disease progression. Here, we examined differences in rest-activity rhythms (RAR) measures, derived from actigraphy, and objective sleep outcomes, derived from electroencephalography (EEG), between 12 CHR and 16 healthy comparison (HC) individuals. Further, we examined the relationships between RAR disturbances, objective sleep outcomes and clinical psychosis symptoms (i.e., negative, positive, disorganized, general symptoms). Sleep-wake behaviors were monitored via actigraphy for 3–7 days (CHR: 5.7 ± 1.7 days; HC: 6.3 ± 1.2 days) prior to participants spending a night in the sleep laboratory, which was monitored with EEG. Separate regressions were used to examine the effect of clinical group on RAR measures and objective sleep outcomes after controlling for age and gender. CHR participants were found to be less active, specifically during the evening (17:00–20:00; β = 1.145, SE = 0.362,p= .004) and nighttime (21:00–24:00; β = 1.152, SE = 0.326,p= .002) relative to HC. Further, CHR participants had more fragmented sleep (wake after sleep onset: β = 0.888, SE = 0.395,p= .034) and more hyperarousal during sleep (NREM gamma activity: β = 1.087, SE = 0.348,p= .005), but these sleep disturbances were not related to reduced activity or clinical symptoms, whereas lower nighttime activity was related to more disorganized symptoms (ρ = −.640,p= .025). Thus, increasing activity through behavioral interventions may have additional beneficial effects on CHR clinical symptoms.