Evaluation of study patients with Lyme disease, 10-20-year follow-up
Evaluation of study patients with Lyme disease, 10-20-year follow-up
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DOI：
10.1086/318082
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发表时间：
2001-02-01
影响因子：
6.4
通讯作者：
Steere, AC
中科院分区：
文献类型：
--
作者：
Kalish, RA;Kaplan, RF;Steere, AC
为了确定莱姆病的长期影响，我们评估了来自康涅狄格州莱姆地区的 84 名随机选择的原始研究患者，这些患者在 10-20 年前患有游走性红斑、面瘫或莱姆关节炎，以及 30 名未感染的对照受试者。 3个研究组和对照组的患者在当前症状或神经心理学测试结果上没有显着差异。然而，面瘫患者通常有更广泛的神经系统受累，更常见的是残留的面部或周围神经缺陷。此外，与接受抗生素治疗的面瘫患者相比，未接受抗生素治疗急性神经疏螺旋体病的面瘫患者现在更常出现关节疼痛和睡眠困难，并且在简短的 36 健康评估问卷中身体疼痛指数和标准化身体成分部分得分较低。因此，每个患者组目前的总体健康状况良好，但后遗症主要在未接受急性神经疏螺旋体病抗生素治疗的面瘫患者中明显。
To determine the long-term impact of Lyme disease, we evaluated 84 randomly selected, original study patients from the Lyme, Connecticut, region who had erythema migrans, facial palsy, or Lyme arthritis 10-20 years ago and 30 uninfected control subjects. The patients in the 3 study groups and the control group did not differ significantly in current symptoms or neuropsychological test results. However, patients with facial palsy, who frequently had more widespread nervous system involvement, more often had residual facial or peripheral nerve deficits. Moreover, patients with facial palsy who did not receive antibiotics for acute neuroborreliosis more often now had joint pain and sleep difficulty and lower scores on the body pain index and standardized physical component sections of the Short-Form 36 Health Assessment Questionnaire than did antibiotic-treated patients with facial palsy. Thus, the overall current health status of each patient group was good, but sequelae were apparent primarily among patients with facial palsy who did not receive antibiotics for acute neuroborreliosis.