Investigation of the rh-catalyzed asymmetric reductive aldol reaction. Expanded scope based on reaction analysis.
Investigation of the rh-catalyzed asymmetric reductive aldol reaction. Expanded scope based on reaction analysis.
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DOI：
10.1021/ol049591e
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发表时间：
2004-06
期刊：
影响因子：
5.2
通讯作者：
A. E. Russell;Nathan O Fuller;Steven J Taylor;Pauline Aurriset;J. Morken
中科院分区：
文献类型：
--
作者：
A. E. Russell;Nathan O Fuller;Steven J Taylor;Pauline Aurriset;J. Morken
[反应：见正文]描述了一系列实验，表明Rh催化的还原Aldol反应是通过将原位生成的Rh(I)氢化物添加到反应的丙烯酸酯中，然后进行立体化学控制的Aldol加成反应进行的。在这个假设的基础上，设计了允许增加底物范围的反应条件。
[reaction: see text] A series of experiments are described that suggest that the Rh-catalyzed reductive aldol reaction proceeds by addition of a Rh(I) hydride, generated in situ, to the reacting acrylate followed by a stereochemistry-controlling aldol addition reaction. On the basis of this hypothesis, reaction conditions are engineered that allow for increased substrate scope.