Multiple functions of general transcription factors TFIIE and TFIIH in transcription: possible points of regulation by trans-acting factors.
Multiple functions of general transcription factors TFIIE and TFIIH in transcription: possible points of regulation by trans-acting factors.
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一般转录因子 TFIIE 和 TFIIH 在转录中的多种功能：反式作用因子的可能调控点。
DOI：
10.1093/oxfordjournals.jbchem.a021777
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发表时间：
1997
影响因子：
2.7
通讯作者：
Yoshiaki Ohkuma
中科院分区：
文献类型：
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作者：
Yoshiaki Ohkuma
一般转录因子与 RNA 聚合酶 II 一起组装在启动子 DNA 上，并响应各种信号准确启动转录。此类信号通过几种替代途径靶向复合物的组分来增强预引发复合物的形成。已知起始复合物的两个成分 TFIIE 和 TFIIH 在转录起始的后期和随后的启动子清除中发挥作用。 TFIIH 因其多种酶活性而受到广泛研究，不仅在转录中发挥作用，而且在核苷酸切除修复和细胞周期控制中发挥作用。 TFIIE 的数据较少，但其对 TFIIH 的潜在监管功能值得进一步关注。在这篇综述中，将全面介绍 TFIIE 和 TFIIH 在转录起始和随后的启动子清除过程中的功能作用，正如最近的研究得出的那样。
General transcription factors together with RNA polymerase II assemble on the promoter DNA and initiate transcription accurately in response to a variety of signals. Such signals enhance preinitiation complex formation by targeting components thereof via several alternative pathways. Two components of the initiation complexes, TFIIE and TFIIH, are known to function at both a late stage of transcription initiation and the following promoter clearance. TFIIH has been studied extensively because of its multiple enzymatic activities, functioning not only in transcription but also in nucleotide excision repair and cell cycle control. Fewer data have been reported for TFIIE, but its potential regulatory function as to TFIIH warrants further attention. In this review, an overall perspective of the functional roles of TFIIE and TFIIH during transcription initiation and the following promoter clearance will be presented as it has emerged from recent studies.