Regional apparent metabolite concentrations in young adult brain measured by 1H MR spectroscopy at 3 tesla
Regional apparent metabolite concentrations in young adult brain measured by 1H MR spectroscopy at 3 tesla
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DOI：
10.1002/jmri.21285
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发表时间：
2008-03-01
影响因子：
4.4
通讯作者：
Horska, Alena
中科院分区：
文献类型：
--
作者：
Baker, Eva H.;Basso, Gianpaolo;Horska, Alena
目的：利用3特斯拉频率下的单体素磁共振光谱定量检测正常年轻人大脑代谢物的分布。材料和方法：采用短回波时间单体素PRESS技术测量年轻人大脑中9个位置5种代谢物的表观浓度。参考未抑制的水信号，通过自动拟合方法（LCModel）估计浓度，并根据T、松弛、T2松弛和脑脊液部分容积进行校正。采用Tukey事后检验方差分析评价区域差异。结果：各代谢物的区域浓度差异有统计学意义。总胆碱差异最大，肌醇差异最小，谷氨酰胺和谷氨酸差异最小。总胆碱变化幅度最大，n -乙酰天冬氨酸和n -乙酰天冬氨酸谷氨酸的总和变化幅度最小。结论：与先前在其他场强下的研究一致，我们发现主要光谱可测量的脑代谢物分布不均。虽然最明显的差异是在组织类型之间，但在不同位置的组织类型内也有明显的变化。所呈现的光谱和代谢物浓度应该为临床和研究在3T进行的MR光谱研究提供有用的参考。
Purpose: To quantify and examine the distribution of brain metabolites in normal young adults using single voxel MR spectroscopy at 3 Tesla M.Materials and Methods: Short-echo time single-voxel PRESS technique was used to measure the apparent concentration of five metabolites at nine locations in the brains of young adults. Concentrations were estimated by means of an automated fitting method (LCModel) with reference to an unsuppressed water signal and were corrected for T, relaxation, T2 relaxation, and cerebrospinal fluid partial volume. Analysis of variance with Tukey post hoc test was used to evaluate regional variations.Results: Statistically significant differences in regional concentrations were detected for each of the metabolites. The number of significant differences was greatest for total choline, whereas myo-inositol and the sum of glutamine and glutamate had the fewest. Magnitude of variation was greatest for total choline and least for the sum of N-acetyl aspartate and N-acetylaspartylglutamate.Conclusion: In agreement with previous studies at other field strengths, we found heterogeneous distribution of the major spectroscopically measurable brain metabolites. Although the most distinct differences are between tissue types, there is appreciable variation within a tissue type at different locations. The spectra and metabolite concentrations presented should provide a useful reference for both clinical and research MR spectroscopy studies performed at 3T.