Additive cytotoxicity of adriamycin and a naturally occurring growth inhibitor extracted from bovine aorta.
Additive cytotoxicity of adriamycin and a naturally occurring growth inhibitor extracted from bovine aorta.
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阿霉素和从牛主动脉提取的天然生长抑制剂的附加细胞毒性。
DOI：
10.1007/bf00176820
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发表时间：
1985
影响因子：
3.4
通讯作者：
Travis,JD
中科院分区：
文献类型：
--
作者：
Haid,M;Cohen,J;Mazariegos,G;Murthy,S;Eisenstein,R;Travis,JD
从牛主动脉中分离出的一种标称分子质量为6K-10K的道尔顿因子，已被证明在培养中能抑制新生血管和肿瘤生长，并能抑制一些肿瘤细胞和内皮细胞的生长。这种名为A-10的因子在组织培养中单独和与阿霉素联合应用对TA3Ha乳腺癌细胞的作用进行了测试。在体外和动物实验中，阿霉素→A-10序列在延缓105个经处理的肿瘤细胞尾部皮下注射可触及的肿瘤方面优于任何一种单独使用的药物。虽然原发肿瘤的生长速度不受这种治疗的影响，但这一序列比单独使用这两种药物在更大程度上延长了生存期。A-10治疗减少了肾上腺转移的数量，但不减少肺、肝或淋巴结的转移。然而，它确实减少了腹主动脉旁淋巴结转移的大小。
A factor of nominal molecular weight 6K–10K Daltons, isolated from bovine aorta, has previously been shown to inhibit neovascularization and tumor growthin vivoand the growth of some tumor cells as well as endothelial cells in culture. This factor, termed A-10, was tested alone and in combination with Adriamycin against TA3Ha mammary adenocarcinoma cells in tissue culture. It was found to have cytotoxicity additive to that of Adriamycin in inhibiting the growth of these cells.In vitroand animal studies show that the sequence of Adriamycin → A-10 is superior to either agent alone in delaying the appearance of palpable tumors after subcutaneous injection of 105pre-treated tumor cells in the tail of strain A mice. While the growth rate of the primary tumor was not affected by such treatment, survival was prolonged to a greater degree by the this sequence than by either of these agents used alone. A-10 treatment reduced the number of metastases to the adrenal gland but not to lung, liver, or lymph nodes. It did, however, reduce the size of metastases to para-aortic lymph nodes.