Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.
Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.
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DOI：
10.1002/eji.201040809
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发表时间：
2011-07
影响因子：
5.4
通讯作者：
Maltzman, Jonathan S.
中科院分区：
文献类型：
--
作者：
Wu, Gregory F.;Corbo, Evann;Schmidt, Michelle;Smith-Garvin, Jennifer E.;Riese, Matthew J.;Jordan, Martha S.;Laufer, Terri M.;Brown, Eric J.;Maltzman, Jonathan S.
The adaptor protein Src homology 2 domain-containing leukocyte-specific protein of 76 kDa (SLP-76) is central to the organization of intracellular signaling downstream of the T cell receptor (TCR). Evaluation of its role in mature, primary T cells has been hampered by developmental defects that occur in the absence of wild-type SLP-76 protein in thymocytes. Following tamoxifen-regulated conditional deletion of SLP-76, mature, antigen-inexperienced T cells maintain normal TCR surface expression but fail to transduce TCR generated signals. Conditionally deficient T cells fail to proliferate in response to antigenic stimulation or a lymphopenic environment. Mice with induced deletion of SLP-76 are resistant to induction of the CD4+ T cell mediated autoimmune disease experimental autoimmune encephalomyelitis. Our findings demonstrate the critical role of SLP-76-mediated signaling in initiating T cell-directed immune responses both in vitro and in vivo and highlight the ability to analyze signaling processes in mature T cells in the absence of developmental defects.
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影响因子：
15.3
作者：
Goldrath, Ananda W;Sivakumar, Pallavur V;Glaccum, Moira;Kennedy, Mary K;Bevan, Michael J;Benoist, Christophe;Mathis, Diane;Butz, Eric A
通讯作者：
Butz, Eric A
DOI：
10.1084/jem.20061805
发表时间：
2007-04-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Purton JF;Tan JT;Rubinstein MP;Kim DM;Sprent J;Surh CD
通讯作者：
Surh CD
影响因子：
30.5
作者：
Reboldi, Andrea;Coisne, Caroline;Sallusto, Federica
通讯作者：
Sallusto, Federica
DOI：
10.1006/bbrc.1997.7124
发表时间：
1997-08-28
影响因子：
3.1
作者：
Feil, R;Wagner, J;Chambon, P
通讯作者：
Chambon, P
影响因子：
4.4
作者：
Kikuchi, K;Kawasaki, Y;Sugamura, K
通讯作者：
Sugamura, K