Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males
Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males
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DOI：
10.1161/hypertensionaha.119.14089
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发表时间：
2020-06-01
期刊：
影响因子：
8.3
通讯作者：
Sullivan, Jennifer C.
中科院分区：
文献类型：
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作者：
Belanger, Kasey M.;Crislip, G. Ryan;Sullivan, Jennifer C.
高血压是心血管疾病最常见的危险因素，每年造成1800多万人死亡。虽然控制血压（BP）的机制在很大程度上仍然未知，但T细胞在高血压的发展中起着关键作用。进一步的证据支持免疫系统在高血压性别差异中的作用。本研究的目的是首先确定性别对DOCA盐高血压男性和女性肾脏T细胞谱的影响，其次检验女性中更多数量的T调节细胞（TcR）保护免受DOCA盐诱导的BP和肾损伤增加的假设。DOCA-盐处理3周后，雄性大鼠的BP增加幅度大于雌性大鼠，尽管两种性别之间的肾损伤增加幅度相当。DOCA盐处理导致两种性别的促炎性T细胞增加;然而，雌性比雄性具有更多的抗炎性T细胞。另外的雄性和雌性DOCA-盐大鼠用抗-CD 25处理以降低TcR。降低TdR仅在女性中显著增加BP，从而消除了BP对DOCA盐反应的性别差异。这些数据支持了这一假设，即TBP可以防止高血压的发展，并且对女性血压的控制特别重要。
Hypertension is the most common risk factor for cardiovascular disease, causing over 18 million deaths a year. Although the mechanisms controlling blood pressure (BP) in either sex remain largely unknown, T cells play a critical role in the development of hypertension. Further evidence supports a role for the immune system in contributing to sex differences in hypertension. The goal of the current study was to first, determine the impact of sex on the renal T-cell profiles in DOCA-salt hypertensive males and females and second, test the hypothesis that greater numbers of T regulatory cells (Tregs) in females protect against DOCA-salt-induced increases in BP and kidney injury. Male rats displayed greater increases in BP than females following 3 weeks of DOCA-salt treatment, although increases in renal injury were comparable between the sexes. DOCA-salt treatment resulted in an increase in proinflammatory T cells in both sexes; however, females had more anti-inflammatory Tregs than males. Additional male and female DOCA-salt rats were treated with anti-CD25 to decrease Tregs. Decreasing Tregs significantly increased BP only in females, thereby abolishing the sex difference in the BP response to DOCA-salt. This data supports the hypothesis that Tregs protect against the development of hypertension and are particularly important for the control of BP in females.