3′-Daidzein sulfonate sodium improves mitochondrial functions afer cerebral ischemia/reperfusion injury
3′-Daidzein sulfonate sodium improves mitochondrial functions afer cerebral ischemia/reperfusion injury
复制标题
3α-大豆苷元磺酸钠改善脑缺血/再灌注损伤后线粒体功能
DOI：
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发表时间：
2017
影响因子：
6.1
通讯作者：
Qiong Lei
中科院分区：
文献类型：
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作者：
Wa Yuan;Qin Chen;Jing Zeng;Hai Xiao;Zhi-hua Huang;Xiao Li;Qiong Lei
3′-Daidzein sulfonate sodium is a new synthetic water-soluble compound derived from daidzein (an active ingredient of the kudzu vine root). It has been shown to have a protective effect on cerebral ischemia/reperfusion injury in rats. We plan to study the mechanism of its protective effect. 3′-Daidzein sulfonate sodium was injected in rats afer cerebral ischemia/reperfusion injury. Results showed that 3′-daidzein sulfonate sodium signifcantly reduced mitochondrial swelling, signifcantly elevated the mitochondrial membrane potential, increased mitochondrial superoxide dismutase and glutathione peroxidase activities, and decreased mitochondrial malondialdehyde levels. 3′-Daidzein sulfonate sodium improved the structural integrity of the blood-brain barrier and reduced blood-brain barrier permeability. Tese fndings confrmed that 3′-daidzein sulfonate sodium has a protective effect on mitochondrial functions afer cerebral ischemia/reperfusion injury, improves brain energy metabolism, and provides protection against blood-brain barrier damage.
