New descriptors of T-wave morphology are independent of heart rate
New descriptors of T-wave morphology are independent of heart rate
复制标题
DOI：
10.1016/j.jelectrocard.2008.07.021
复制
发表时间：
2008-11-01
影响因子：
1.3
通讯作者：
Struijk, Johannes J.
中科院分区：
文献类型：
--
作者：
Andersen, Mads P.;Xue, Joel Q.;Struijk, Johannes J.
T波形态描述符对药物引起的变化敏感，可能是心脏安全性试验中QT间期的有用补充。在39名健康个体的样本中研究了T波形态的受试者心率依赖性。从日间Holier记录中获得10秒心电图。自动测量持续时间参数（QT、ToTe、TpTe等）、许多基本T波形态参数（振幅、面积等）以及高级形态描述符（不对称性、平坦度等）。通过协方差分析检查心率依赖性。结果显示QT间期具有明显的心率依赖性（R-2 = 0.53-0.57），基本形态学参数（振幅、面积等）具有中度心率依赖性（R-2 = 0.17-0.42）。两种高级T波描述符（不对称性、平坦度等）ToTe间期和TpTe间期实际上与心率无关（R-2 = 0-0.08），因此无需对这些参数进行心率校正。(C)2008年爱思唯尔公司All rights reserved.
T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holier recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R-2 = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R-2 = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R-2 = 0-0.08), making heart rate correction unnecessary for these parameters. (C) 2008 Elsevier Inc. All rights reserved.