Indoor volatile organic compounds and chemical sensitivity reactions.
Indoor volatile organic compounds and chemical sensitivity reactions.
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DOI：
10.1155/2013/623812
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发表时间：
2013
影响因子：
--
通讯作者：
Kunugita N
中科院分区：
文献类型：
--
作者：
Win-Shwe TT;Fujimaki H;Arashidani K;Kunugita N
对化学敏感受试者中观察到的不明原因症状的研究提高了人们对由于暴露于挥发性有机化合物（VOC）而导致的神经系统和免疫系统疾病之间关系的认识。然而，没有直接证据表明暴露于低剂量的VOC与神经和免疫功能障碍有关。我们回顾动物模型数据，以澄清挥发性有机化合物在神经免疫相互作用中的作用，并讨论我们最近的研究表明，C3 H小鼠慢性暴露于低水平的甲醛和诱导神经和免疫功能障碍之间的关系。我们还考虑了VOC暴露可能引起多种化学敏感性患者出现症状的可能机制。
Studies of unexplained symptoms observed in chemically sensitive subjects have increased the awareness of the relationship between neurological and immunological diseases due to exposure to volatile organic compounds (VOCs). However, there is no direct evidence that links exposure to low doses of VOCs and neurological and immunological dysfunction. We review animal model data to clarify the role of VOCs in neuroimmune interactions and discuss our recent studies that show a relationship between chronic exposure of C3H mice to low levels of formaldehyde and the induction of neural and immune dysfunction. We also consider the possible mechanisms by which VOC exposure can induce the symptoms presenting in patients with a multiple chemical sensitivity.