Evolution of the active sequences of the HpaI short interspersed elements
Evolution of the active sequences of the HpaI short interspersed elements
复制标题
HpaI短散布元件活性序列的进化
DOI：
10.1007/bf00173180
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发表时间：
1995
影响因子：
3.9
通讯作者：
N. Okada
中科院分区：
文献类型：
--
作者：
Y. Kido;M. Saitoh;S. Murata;N. Okada
对短散布重复元件 (SINE) 的鲑鱼 HpaI 和 AvaIII 家族的 99 个成员进行了比对，并推导出了一般共有序列。共有序列中核苷酸（诊断核苷酸）中存在 26 个相关变化，使我们能够将 HpaI 家族的成员分为 12 个亚家族，将 AvaIII 家族的成员分为两个亚家族。根据亚科的平均序列分歧和系统发育分布，推断出亚科的相对古老性以及各个源序列的连续变化过程。尽管在个体分散成员中CG二核苷酸的突变率较高，但在源序列的变化中没有观察到CG位置的超突变。这一结果表明，位于非甲基化或低甲基化基因组区域的 SINE 序列可能已被选择作为逆位的源序列和/或某些 CG 位点是逆位机制的识别序列的一部分。
Ninety-nine members of the salmonid HpaI and AvaIII families of short interspersed repetitive elements (SINEs) were aligned and a general consensus sequence was deduced. The presence of 26 correlated changes in nucleotides (diagnostic nucleotides) from those in the consensus sequence allowed us to divide the members of the HpaI family into 12 subfamilies and those of the AvaIII family into two subfamilies. On the basis of the average sequence divergences and the phylogenetic distributions of the subfamilies, the relative antiquity of the subfamilies and the process of sequential changes in the respective source sequences were inferred. Despite the higher mutation rates of CG dinucleotides in individual dispersed members, no hypermutability of CG positions was observed in changes in the source sequences. This result suggests that sequences of SINEs located in a nonmethylated or hypomethylated genomic region could have been selected as source sequences for retroposition and/or that some CG sites are the parts of recognition sequences of retropositional machineries.
鉴定海胆基因组中的重复序列，该序列由 RNA 聚合酶 III 转录并包含反座子的特征。
影响因子：
14.9
作者：
Nisson,PE;Hickey,RJ;Boshar,MF;CrainJr,WR
通讯作者：
CrainJr,WR