Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity.
Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity.
复制标题
DOI：
10.1038/ajh.2011.87
复制
发表时间：
2011-09
影响因子：
3.2
通讯作者：
Blumentnal, James A.
中科院分区：
文献类型：
--
作者：
Sherwood, Andrew;Routledge, Faye S.;Wohlgemuth, William K.;Hinderliter, Alan L.;Kuhn, Cynthia M.;Blumentnal, James A.
关键词：
钝性血压下降是不良心血管结局的既定预测因素。虽然非裔美国人的血压下降比白人更常见，但造成这种种族差异的因素还不清楚。本研究探讨了血压下降与种族、体重指数、睡眠质量和睡眠期间交感神经系统活动下降的关系。在3个场合，128名未经治疗的高门诊血压（130-159/85-99 mmHg）参与者接受了24小时动态血压，睡眠质量（通过睡眠访谈，自我报告，活动记录法评估）和睡眠期交感神经活动下降（通过清醒/睡眠尿儿茶酚胺排泄测量）的评估。与白人（n=72）相比，非裔美国人（n=56）表现出较高的睡眠期收缩压（p= 0.01）和舒张压（p<0.001），收缩压下降平缓（p= 0.01），体重指数较高（p= 0.049）和睡眠质量较差（p= 0.02）。收缩压下降与体重指数（r=-0.32，p<0.001）、睡眠质量（r=0.30，p<0.001）和睡眠期交感神经活动下降（r=0.30，p<0.001）相关。多元回归分析表明，这3个因素是睡眠期收缩压下降的独立决定因素;控制这些因素后，下降的种族差异减弱。钝性血压下降与较高的体重指数，较差的睡眠质量，以及睡眠期间交感神经系统活动的下降较少有关。虽然在未经调整的分析中，与白人相比，非洲裔美国人的种族也与钝化下降有关，但当考虑到体重指数，睡眠质量和交感神经活动时，这种种族差异就会减少。
Blunted blood pressure dipping is an established predictor of adverse cardiovascular outcomes. Although blunted blood pressure dipping is more common in African Americans than whites, the factors contributing to this ethnic difference are not well understood. This study examined the relationships of blood pressure dipping to ethnicity, body mass index, sleep quality, and fall in sympathetic nervous system activity during the sleep-period. On 3 occasions, 128 participants with untreated high clinic blood pressure (130–159/85–99 mmHg) underwent assessments of 24-hour ambulatory blood pressure, sleep quality (evaluated by sleep interview, self-report, actigraphy) and sleep-period fall in sympathetic activity (measured by waking/sleep urinary catecholamine excretion). Compared to whites (n=72), African Americans (n=56) exhibited higher sleep-period systolic (p=.01) and diastolic blood pressure (p<.001), blunted systolic blood pressure dipping (p=.01), greater body mass index (p=.049) and poorer sleep quality (p=.02). Systolic blood pressure dipping was correlated with body mass index (r=−0.32, p<.001), sleep quality (r=0.30, p<.001), and sleep-period fall in sympathetic activity (r=0.30, p<.001). Multiple regression analyses indicated that these 3 factors were independent determinants of sleep-period systolic blood pressure dipping; ethnic differences in dipping were attenuated when controlling for these factors. Blunted blood pressure dipping was related to higher body mass index, poorer sleep quality, and a lesser decline in sleep-period sympathetic nervous system activity. Although African American ethnicity also was associated with blunted dipping compared to whites in unadjusted analyses, this ethnic difference was diminished when body mass index, sleep quality and sympathetic activity were taken into account.
登录
查看更多内容
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
2.7
作者：
Kagan, A.;Faibel, H.;Rapoport, J.
通讯作者：
Rapoport, J.
影响因子：
1.9
作者：
OBRIEN, PC
通讯作者：
OBRIEN, PC
影响因子：
5.6
作者：
Friedman, Oded;Logan, Alexander G.
通讯作者：
Logan, Alexander G.
影响因子：
1.3
作者：
Goodwin, James;Bilous, Mary;Jones, Stephen C.
通讯作者：
Jones, Stephen C.