Proteolytic control of regulated necrosis
Proteolytic control of regulated necrosis
复制标题
DOI：
10.1016/j.bbamcr.2017.05.025
复制
发表时间：
2017-11-01
影响因子：
5.1
通讯作者：
Adam, Dieter
中科院分区：
文献类型：
--
作者：
Chico, Johaiber Fuchslocher;Saggau, Carina;Adam, Dieter
蛋白酶控制细胞中发生的大部分生理过程。这特别适用于细胞凋亡，细胞死亡的最充分研究的形式，其中半胱氨酸-天冬氨酸蛋白酶（半胱氨酸天冬氨酸蛋白酶）的蛋白水解是细胞自杀的启动和执行的主要机制。相比之下，蛋白水解对其他非凋亡细胞死亡途径的影响（总结为术语“调节性坏死”，RN）长期以来一直是个谜，但最近的一些突破性发现已经明确证实。在这里，我们回顾这些发现，并提供了一个概述蛋白水解的作用，在已知形式的RN，特别关注坏死性凋亡和焦亡，以及它们的调节去泛素化酶，凋亡和炎性半胱氨酸蛋白酶。本文是Stefan Rose-John编辑的特刊的一部分，标题为：蛋白质分解作为病理生理学中的调节事件。
Proteases control most of the physiological processes that occur in a cell. This particularly applies to apoptosis, the most well-studied form of cell death, where proteolysis by cysteine-aspartic proteases (caspases) is the primary mechanism for both initiation and execution of cell suicide. In contrast, the impact of proteolysis on other, non-apoptotic cell death pathways (summarized under the term "regulated necrosis", RN) has long been enigmatic, but has clearly been confirmed by a number of recent groundbreaking discoveries. Here, we review these discoveries and provide an overview on the role of proteolysis in known forms of RN, with a particular focus on necroptosis and pyroptosis, and their regulation by deubiquitinases, apoptotic and inflammatory caspases. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John.