Neuroprotective effect of asymmetric dimethylarginine against 1‐methyl‐4‐phenylpyridinium ion‐induced damage in PC12 cells
Neuroprotective effect of asymmetric dimethylarginine against 1‐methyl‐4‐phenylpyridinium ion‐induced damage in PC12 cells
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DOI：
10.1111/j.1440-1681.2010.05344.x
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发表时间：
2010-05
影响因子：
2.9
通讯作者：
Xiao-Qing Tang;Yu-juan Li;Jing Zhao-;Xin-Tian Shen;Chun-tao Yang;Li-li Fan;Bi Hu;Yuan‐jian Li;
中科院分区：
文献类型：
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作者：
Xiao-Qing Tang;Yu-juan Li;Jing Zhao-;Xin-Tian Shen;Chun-tao Yang;Li-li Fan;Bi Hu;Yuan‐jian Li;
1.不对称二甲基精氨酸（ADMA）是一种众所周知的内源性一氧化氮合酶（NOS）抑制剂。虽然它已被证明是心血管药物和慢性肾脏疾病的一种新的风险标志物，但我们推测，在某些与过量一氧化氮（NO）相关的状态下，例如1-甲基-4-苯基吡啶离子（MPP+）诱导的神经元损伤，ADMA可能通过限制高浓度NO的毒性作用而具有保护作用。
1. Asymmetric dimethylarginine (ADMA) is a well‐known endogenous nitric oxide synthase (NOS) inhibitor. Although it has been shown to be a novel risk marker in cardiovascular medicine and chronic kidney disease, we speculated that in some states associated with excess of nitric oxide (NO), such as 1‐methyl‐4‐phenylpyridinium ion (MPP+)‐induced neuronal injury, ADMA might be protective by limiting the toxic effect of high concentrations of NO.