Six months clinical, angiographic, and IVUS follow-up after PTFE graft stent implantation in native coronary arteries
Six months clinical, angiographic, and IVUS follow-up after PTFE graft stent implantation in native coronary arteries
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DOI：
10.2143/ac.55.4.2005748
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发表时间：
2000-08-01
影响因子：
1.6
通讯作者：
Benit, E
中科院分区：
文献类型：
--
作者：
Lukito, G;Vandergoten, P;Benit, E
导言--支架植入后再狭窄仍然是一个问题。一个重要的突破是使用移植物支架，作为血流和血管壁之间的机械屏障，通过更有限的增殖和最小的移植物组织穿透可能导致较少的再狭窄。目的-评估一种新的球囊可膨胀冠状动脉聚四氟乙烯(PTFE(R))移植物支架(JMED(R))的急性和6个月的临床、血管造影和IVUS结果。方法10例冠状动脉近端狭窄较短(长度小于或等于15 mm)的患者，选择性植入支架(19 mm支架，15 mm移植物)。分别于植入前、植入后即刻和植入后6个月进行临床评估、定量冠状动脉造影(QCA)和冠状动脉内超声(IVUS)检查。结果治疗冠状动脉病变：右冠状动脉7例，左冠状动脉2例，左前降支1例。平均球囊直径为3.7 mm，平均充气压力为18atm(min.最多12个月23)。另有3例患者需行支架置入。2例患者CK轻度升高(250IU/I)，1例患者需要输血。无1例患者发生(亚)急性或晚期血栓形成。如表所示，移植血管支架体内未见再狭窄，2例患者支架近端和/或远端未被移植血管覆盖。1例支架外再狭窄。所有患者在6个月随访(FU)时均无症状，负荷试验为阴性。
Introduction - Restenosis remains a problem even after stent implantation. An important breakthrough could be the use of graft stents, functioning as a mechanical barrier between the blood flow and the vessel wall, and possibly inducing less restenosis by more limited hyperplasia and minimal transgraft tissue penetration.Objective - To assess the acute and 6 months clinical, angiographic and IVUS results of a new balloon expandable coronary polytetrafluoroethylene (PTFE) graft stent (Jomed(R)).Method - Ten patients with a short (less than or equal to 15 mm length) de novo proximal stenosis in a large (greater than or equal to 3 mm diameter) coronary artery were treated by elective implantation of a graft stent (19 mm stent, 15 mm graft). Clinical assessment, quantitative coronary angiography (QCA) and intracoronary ultrasound (IVUS) were performed before, immediately after and 6 months after implantation. A stress test was also done at 6 months.Results - The coronary arteries treated were: RCA in 7 patients, LCX in 2 patients, LAD in 1 patient. Mean balloon size was 3.7 mm diameter, and mean inflation pressure was 18 atm (min. 12, max. 23). Additional stenting was needed in 3 patients. Two patients showed a minimal rise in CK (< 250 IU/I) and 1 patient needed a transfusion.No patient experienced a (sub)acute nor late thrombosis.As shown in the table, no restenosis was seen in the body of the graft stent, in 2 patients a restenosis was detected in the proximal and/or distal parts of the stent which are not covered by the graft. In 1 patient a restenosis was found outside the stent. All patients remained asymptomatic with a negative stress test at 6 months follow-up (FU).