Magnetization transfer MRS
Magnetization transfer MRS
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DOI：
10.1002/nbm.681
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发表时间：
2001-04-01
影响因子：
2.9
通讯作者：
Dreher, W
中科院分区：
文献类型：
--
作者：
Leibfritz, D;Dreher, W
本文综述了在体内核磁共振光谱中观察到的磁化转移效应。描述了MT实验的基本实验方法、潜在的动力学机制以及通过拟合两池或三池模型对测量数据的评估，回顾了P-31和H-1体内MRS的实验结果，显示了MT实验表征动力学平衡反应的潜力。这包括所有相关成分都是MR可见的反应，以及间接测量无法在活体中直接观察到的束缚自旋池的情况。特别是，描述了在动物或人类大脑或骨骼肌上测量的体内H-1核磁共振光谱中观察到的MT效应。讨论了对肌酸/磷酸肌酸、乳酸、酒精和其他代谢物信号观察到的强MT效应的可能机制。同时强调了水抑制技术引起的MT效应可能导致H-1核磁共振谱定量的系统误差。版权所有John Wiley & Sons， Ltd。
This review deals with magnetization transfer (MT) effects observed in in vivo NMR spectroscopy. The basic experimental methods of MT experiments, the underlying kinetic mechanisms as well as the evaluation of measured data by fits to two- or three-pool models are described, Experimental results of both P-31 and H-1 in vivo MRS are reviewed showing the potential of MT experiments to characterize kinetic equilibrium reactions. This includes reactions where all involved components are MR visible, as well as situations where one indirectly measures pools of bound spins which cannot directly be observed in vive. In particular, MT effects are described which have been observed in in vivo H-1 NMR spectra measured on the animal or human brain or on skeletal muscle. Possible mechanisms for the strong MT effects observed for the signals of creatine/phosphocreatine, lactate, alcohol and other metabolites are discussed. It is also emphasized that MT effects caused by water suppression techniques may lead to systematic errors in the quantification of in vive H-1 NMR spectra. Copyright (C) 2001 John Wiley & Sons, Ltd.