Effects of acute and chronic 1,3-butanediol treatment on central nervous system function: a comparison with ethanol.
Effects of acute and chronic 1,3-butanediol treatment on central nervous system function: a comparison with ethanol.
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急性和慢性 1,3-丁二醇治疗对中枢神经系统功能的影响：与乙醇的比较。
DOI：
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发表时间：
1981
影响因子：
3.5
通讯作者：
G. Breese
中科院分区：
文献类型：
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作者：
G. Frye;Robert E. Chapin;R. Vogel;R. Mailman;Clinton D. Kilts;R. A. Mueller;G. Breese
本研究比较了1，3-丁二醇（1，3-BD）和乙醇的神经药理作用。对大鼠急性腹腔注射等摩尔剂量的1，3-BD或乙醇会损害空中翻正反射，减弱惩罚对饮酒行为的抑制作用，降低血压，同时导致小脑中鸟苷3 '，5'-一磷酸含量减少，并减少乙醇戒断反应。尽管这些数据表明乙醇和2，3-BD具有相似的效力，但在等摩尔剂量处理后，1，3-BD的脑含量仅为乙醇的33%，表明1，3-BD具有更大的中枢神经系统（CNS）效力。在长期用乙醇治疗以产生身体依赖的大鼠中，1，3-BD在抑制乙醇戒断后观察到的过度兴奋方面比乙醇更有效。此外，慢性给药和停药1，3-BD导致大鼠CNS过度兴奋，这是身体依赖的特征。尽管有这些相似之处，但乙醇和1，3-BD的作用存在明显差异。在小鼠中，乙醇引起的运动刺激后，1，3-BD没有观察到。此外，虽然1，3-BD没有改变血浆中促黄体生成素的浓度，等效剂量的乙醇显着降低这种激素的浓度。这些数据表明，像乙醇一样，1，3-BD抑制CNS活性并诱导身体依赖性，但对血浆促黄体激素浓度的影响小于乙醇。
In the present investigation, the neuropharmacology of 1,3 butanediol (1,3-BD) was compared with that of ethanol. Acute i.p. administration of equimolar doses of 1,3-BD or ethanol to rats impaired the aerial righting reflex, attenuated the suppressive effect of punishment on drinking behavior, lowered blood pressure, caused a concomitant reduction in the content of guanosine 3',5'-monophosphate in the cerebellum and reduced ethanol withdrawal reactions. Although these data suggested that ethanol and 2,3-BD were of similar potency, the brain content of 1,3-BD was only 33% of that of ethanol after treatment with equimolar doses, suggesting a greater central nervous system (CNS) potency for 1,3-BD. In rats treated chronically with ethanol to produce physical dependence, 1,3-BD was more potent than ethanol in inhibiting the hyperexcitability observed upon ethanol withdrawal. Furthermore, chronic administration and withdrawal of 1,3-BD caused CNS hyperexcitability in rats that was characteristic of physical dependence. Despite these similarities, there were clear differences in the actions of ethanol and 1,3-BD. In mice, locomotor stimulation caused by ethanol was not observed after 1,3-BD. Furthermore, while 1,3-BD did not alter the concentration of luteinizing hormone in plasma, equivalent doses of ethanol markedly reduced the concentration of this hormone. These data indicate that like ethanol, 1,3-BD depresses CNS activity and induces physical dependence, but has less effect on plasma luteinizing hormone concentration than ethanol.