Ways to control harmful biofilms: prevention, inhibition, and eradication.
Ways to control harmful biofilms: prevention, inhibition, and eradication.
复制标题
控制有害生物膜的方法：预防、抑制和根除
DOI：
10.1080/1040841x.2020.1842325
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发表时间：
2021-03
影响因子：
6.5
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Yin W;Xu S;Wang Y;Zhang Y;Chou SH;Galperin MY;He J
生物膜是一种复杂的微生物结构，它将微生物细胞包裹在由自身产生的胞外聚合物组成的基质中。与浮游生物相比，生活在生物膜中的微生物对恶劣环境的抵抗力更强，对杀菌剂的抵抗力也更强。从人类的角度来看，生物膜可分为有益、中性和有害三种。有害生物膜影响食品安全，引发动植物疾病，威胁医学领域，迫切需要制定有效而有力的战略来控制有害生物膜。在这篇综述中，我们讨论了控制感染组织、植入物和医疗器械上生物膜形成的各种策略。我们将目前的策略分为三大类：(I)改变敏感表面的性质以防止生物膜的形成；(Ii)调节信号通路以抑制生物膜的形成；(Iii)施加外力以根除生物膜。我们希望这项审查将推动制定控制有害生物膜的创新和有效战略。
Biofilms are complex microbial architectures that encase microbial cells in a matrix comprising self-produced extracellular polymeric substances. Microorganisms living in biofilms are much more resistant to hostile environments than their planktonic counterparts and exhibit enhanced resistance against the microbicides. From the human perspective, biofilms can be classified into beneficial, neutral, and harmful. Harmful biofilms impact food safety, course plant and animal diseases, and threaten medical fields, making it urgent to develop effective and robust strategies to control harmful biofilms. In this review, we discuss various strategies to control biofilm formation on infected tissues, implants, and medical devices. We classify the current strategies into three main categories: (i) changing the properties of susceptible surfaces to prevent biofilm formation; (ii) regulating signaling pathways to inhibit biofilm formation; (iii) applying external forces to eradicate the biofilm. We hope this review would motivate the development of innovative and effective strategies for controlling harmful biofilms.