INVITED COMMENTARY POTENTIAL CONTRIBUTION OF THE GLUTATHIONE-S-TRANSFERASE SUPERGENE FAMILY TO RESISTANCE TO OXIDATIVE STRESS
INVITED COMMENTARY POTENTIAL CONTRIBUTION OF THE GLUTATHIONE-S-TRANSFERASE SUPERGENE FAMILY TO RESISTANCE TO OXIDATIVE STRESS
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DOI：
10.3109/10715769509147539
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发表时间：
1995-01-01
影响因子：
3.3
通讯作者：
STRANGE, RC
中科院分区：
文献类型：
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作者：
HAYES, JD;STRANGE, RC
谷胱甘肽S转移酶(GST)超基因家族由编码同工酶的基因家族组成，这些同工酶广泛表达于哺乳动物组织、胞浆和细胞膜中。胞质(特别是由α、u和theta基因家族编码的同工酶)和微体GST都能催化还原型谷胱甘肽(GSH)与各种亲电物质的结合，这些亲电物质包括已知的致癌物以及各种氧化应激产物，包括氧化的DNA和脂质。事实上，有几条证据表明，这些同工酶中的某些在保护细胞免受这种压力的影响方面发挥了关键作用。然而，目前很难评估这些GST在人类中的重要性，因为阿尔法和西塔类基因的数量尚不清楚，即使已识别的异构体的催化偏好也不总是明确的。
The glutathione S-transferase (GST) supergene family comprises gene families that encode isoenzymes that are widely expressed in mammalian tissue cytosols and membranes. Both cytosolic (particularly the isoenzymes encoded by the alpha, mu and theta gene families) and microsomal GST catalyse the conjugation of reduced glutathione (GSH) with a wide variety of electrophiles which include known carcinogens as well as various compounds that are products of oxidative stress including oxidised DNA and lipid. Indeed, several lines of evidence suggest certain of these isoenzymes play a pivotal role in protecting cells from the consequences of such stress. An assessment of the importance of these GST in humans is presently difficult however, because the number of alpha and theta class genes is not known and, the catalytic preferences of even identified isoforms is not always clear.