[Discovery, anatomical mapping and biosynthesis of various families of endogenous opioid peptides].
[Discovery, anatomical mapping and biosynthesis of various families of endogenous opioid peptides].
复制标题
[内源性阿片肽各家族的发现、解剖图谱和生物合成]。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
J. Rossier
中科院分区：
文献类型：
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作者：
G. Patey;J. Rossier
内源性阿片肽在其氨基末端均含有脑啡肽序列Tyr-Gly-Gly-Phe（-Met/-Leu）。这些肽的三个不同家族（β-内啡肽、脑啡肽和强啡肽）存在于中枢神经系统内的不同神经元通路中。分子遗传学表明，这三个阿片肽家族源自三种不同的前体。阿黑皮素原产生内啡肽，以及促肾上腺皮质激素（ACTH）和促黑素激素（MSH）。Met-脑啡肽、Leu-脑啡肽和相关的七肽Met-脑啡肽-Arg 6-Phe 7和八肽Met-脑啡肽-Arg 6-Gly 7-Leu 8衍生自脑啡肽原。第三家族源自强啡肽原，包括强啡肽A、强啡肽B（也称为rimorphin）以及α-和β-新内啡肽。编码这些前体的基因的结构相似，这表明可能存在一个共同的祖先基因。目前的主要问题是内源性阿片肽如此多样性的生理意义。
The endogenous opioid peptides all contain the enkephalin sequence Tyr-Gly-Gly-Phe (-Met/-Leu at their amino-terminus. Three distinct families of these peptides (beta-endorphins, enkephalins and dynorphins) are present in different neuronal pathways within the central nervous system. Molecular genetics have shown that these three families of opioid peptides are derived from three distinct precursors. Pro-opiomelanocortin gives rise to the endorphins, as well as adrenocorticotropic hormone (ACTH) and the melanotropic hormones (MSH's). Met-enkephalin, Leu-enkephalin and the related heptapeptide Met-enkephalin-Arg6-Phe7 and octapeptide Met-enkephalin-Arg6-Gly7-Leu8 are derived from proenkephalin. The third family is derived from prodynorphin and includes dynorphin A, dynorphin B (also known as rimorphin) and alpha- and beta-neo-endorphin. The structures of the genes coding for these precursors are similar, suggesting the possibility of one common ancestral gene. At the present time the main question concerns the physiological significance of such a great diversity of endogenous opioid peptides.