Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
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DOI：
10.1152/japplphysiol.00246.2003
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发表时间：
2003-11-01
影响因子：
3.3
通讯作者：
Ferrucci, L
中科院分区：
文献类型：
--
作者：
Lauretani, F;Russo, CR;Ferrucci, L
肌肉减少症，即随着年龄的增长而发生的肌肉质量和力量的减少，被广泛认为是老年人残疾的主要原因之一。令人惊讶的是，仍然缺乏可以帮助临床医生识别肌肉功能受损的人的标准。使用来自一般人群的大量代表性样本的数据，我们研究了肌肉功能和小腿肌肉面积如何随着年龄的增长而变化，并影响无神经系统疾病的男性和女性的活动性。我们测试了几个肌肉减少症的推定指标，包括膝关节伸展等长扭矩，握力，下肢肌肉力量和小腿肌肉面积。对于每个指标，当测量值低于平均值> 2个SD时，认为存在肌肉减少症。对于所有四种措施，肌肉减少症的患病率随着年龄的增长而增加，无论是男性还是女性。年龄相关的患病率梯度是最大的肌肉力量和小腿肌肉面积最小。然而，下肢肌肉力量在早期识别活动性差（定义为步行速度）方面并不比膝关节伸展扭矩或握力好
Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to identify persons with impaired muscle function are still lacking. Using data from a large representative sample of the general population, we examined how muscle function and calf muscle area change with aging and affect mobility in men and women free of neurological conditions. We tested several putative indicators of sarcopenia, including knee extension isometric torque, handgrip, lower extremity muscle power, and calf muscle area. For each indicator, sarcopenia was considered to be present when the measure was >2 SDs below the mean. For all four measures, the prevalence of sarcopenia increased with age, both in men and women. The age-associated gradient in prevalence was maximum for muscle power and minimum for calf-muscle area. However, lower extremity muscle power was no better than knee-extension torque or handgrip in the early identification of poor mobility, defined either as walking speed