Total synthesis of a sialyl Lewisx derivative for the diagnosis of cancer
Total synthesis of a sialyl Lewisx derivative for the diagnosis of cancer
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DOI：
10.1016/j.carres.2013.11.012
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发表时间：
2014-01-13
影响因子：
3.1
通讯作者：
Zhang, Yongmin
中科院分区：
文献类型：
--
作者：
Lu, Dan;Hu, Yongzhou;Zhang, Yongmin
The total synthesis of aminoethyl glycoside of sialyl Lewis(x) (sLe(x)) is described. A galactose donor was condensed with a diol of glucosamine to afford regioselectively a beta 1,4 linked disaccharide, which was further stereoselectively fucosylated to provide a protected Lewisx trisaccharide. After chemical modification, the trisaccharide was sialylated to give regio- and stereoselectively an azidoethyl glycoside of sLe(x). Finally, deprotection and azide reduction afforded the target compound. This compound will be coupled with protein and then be used to conduct further preclinical studies for the diagnosis of cancer. (C) 2013 Elsevier Ltd. All rights reserved.
