The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification.
The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification.
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发表时间：
2000-09
期刊：
影响因子：
4.6
通讯作者：
Marthe J. Howard;M. Stanke;Carolin Schneider;Xiaodong Wu;Hermann Rohrer
中科院分区：
文献类型：
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作者：
Marthe J. Howard;M. Stanke;Carolin Schneider;Xiaodong Wu;Hermann Rohrer
dHAND碱性螺旋-环-螺旋转录因子在交感神经节的神经元中表达，并且先前已显示在禽类神经嵴培养物中诱导儿茶酚胺能神经元的分化。我们现在证明，dHAND表达是足以引起异位交感神经元在体内的产生。dHAND基因的表达受骨形态发生蛋白（BMP）控制，正如体内和体外BMP 4过表达以及体内头蛋白介导的BMP功能抑制所表明的那样。交感神经节原基中dHAND表达的时间，连同响应于Phox2b的dHAND表达的诱导暗示了dHAND作为Phox2b下游的转录调节因子在BMP诱导的交感神经元分化中的作用。
The dHAND basic helix-loop-helix transcription factor is expressed in neurons of sympathetic ganglia and has previously been shown to induce the differentiation of catecholaminergic neurons in avian neural crest cultures. We now demonstrate that dHAND expression is sufficient to elicit the generation of ectopic sympathetic neurons in vivo. The expression of the dHAND gene is controlled by bone morphogenetic proteins (BMPs), as suggested by BMP4 overexpression in vivo and in vitro, and by noggin-mediated inhibition of BMP function in vivo. The timing of dHAND expression in sympathetic ganglion primordia, together with the induction of dHAND expression in response to Phox2b implicate a role for dHAND as transcriptional regulator downstream of Phox2b in BMP-induced sympathetic neuron differentiation.