Infection Complications in Hematopoietic Stem Cells Transplant Recipients: Do Genetics Really Matter?
Infection Complications in Hematopoietic Stem Cells Transplant Recipients: Do Genetics Really Matter?
复制标题
DOI：
10.3389/fmicb.2018.02317
复制
发表时间：
2018
影响因子：
5.2
通讯作者：
Takami A
中科院分区：
文献类型：
--
作者：
Espinoza JL;Wadasaki Y;Takami A
造血干细胞移植（HSCT）是一种高度先进的技术，为越来越多的危及生命的疾病提供了潜在的治疗方法。在过去十年中取得的巨大进展，包括供体选择的改进和患者支持性护理的进步，显着改善了移植结果;然而，侵袭性感染，移植物与宿主疾病（GVHD）和其它严重并发症仍然是HSCT接受者发病率和死亡率的主要来源。由于移植前条件作用导致的解剖屏障损伤、严重受损的免疫功能和肠道微生物群落（肠道微生物群）组成的严重破坏是移植程序固有的改变，这些改变直接涉及侵入性感染和其他HSCT并发症的发展。虽然HLA匹配代表移植结果的最重要的遗传预测因子，但非HLA基因中的遗传变异，特别是编码与对组织损伤和病原体感染的免疫应答相关的蛋白质的基因的单核苷酸多态性（SNP）也被认为是涉及HSCT并发症发生的额外风险因素。此外，尽管微生物群的组成受多种因素的影响，但最近的证据表明，某些宿主遗传变异与肠道微生物组的组成改变有关，因此可能使一些个体易患侵入性感染并发症。本文总结了目前对非HLA基因中遗传变异对HSCT受者感染性并发症发生的影响的认识。
Hematopoietic stem cell transplantation (HSCT) is a highly advanced technique that offers a potential cure for an increasing number of life-threatening diseases. Enormous progress achieved in the last decade, including the refinement of donor selection and advancements in patient supportive care, had significantly improved transplant outcomes; however, invasive infections, graft-vs.-host disease (GVHD) and other serious complications still represent a major source of morbidity and mortality in HSCT recipients. The damage of anatomical barriers due to pre-transplant conditioning, a severely damaged immune function and a profound disruption in the composition of gut microbial commensals (gut microbiota) are alterations inherent to the transplant procedure that are directly implicated in the development of invasive infections and other HSCT complications. Although HLA-matching represents the most important genetic predictor of transplant outcomes, genetic variants in non-HLA genes, especially single nucleotide polymorphisms (SNPs) of genes encoding proteins associated with the immune response to tissue injury and pathogen infection have also been proposed as additional risk factors implicated in the occurrence of HSCT complications. Furthermore, although the microbiota composition is affected by several factors, recent evidence suggests that certain host genetic variants are associated with an altered composition of the gut microbiome and may, therefore, predispose some individuals to invasive infectious complications. This article summarizes the current understanding of the influence that genetic variants in non-HLA genes have on the development of infectious complications in HSCT recipients.
登录
查看更多内容
DOI：
10.1056/nejmoa0802629
发表时间：
2008-10-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bochud PY;Chien JW;Marr KA;Leisenring WM;Upton A;Janer M;Rodrigues SD;Li S;Hansen JA;Zhao LP;Aderem A;Boeckh M
通讯作者：
Boeckh M
影响因子：
2.2
作者：
Aki, Kyoko;Okubo, Yoichiro;Shibuya, Kazutoshi
通讯作者：
Shibuya, Kazutoshi
影响因子：
25.7
作者：
Folseraas, Trine;Melum, Espen;Rausch, Philipp;Juran, Brian D.;Ellinghaus, Eva;Shiryaev, Alexey;Laerdahl, Jon K.;Ellinghaus, David;Schramm, Christoph;Weismueller, Tobias J.;Gotthard, Daniel Nils;Hov, Johannes Roksund;Clausen, Ole Petter;Weersma, Rinse K.;Janse, Marcel;Boberg, Kirsten Muri;Bjornsson, Einar;Marschall, Hanns-Ulrich;Cleynen, Isabelle;Rosenstiel, Philip;Holm, Kristian;Teufel, Andreas;Rust, Christian;Gieger, Christian;Wichmann, H-Erich;Bergquist, Annika;Ryu, Euijung;Ponsioen, Cyriel Y.;Runz, Heiko;Sterneck, Martina;Vermeire, Severine;Beuers, Ulrich;Wijmenga, Cisca;Schrumpf, Erik;Manns, Michael P.;Lazaridis, Konstantinos N.;Schreiber, Stefan;Baines, John F.;Franke, Andre;Karlsen, Tom H.
通讯作者：
Karlsen, Tom H.
影响因子：
7.4
作者：
Beaumont, Martin;Andriamihaja, Mireille;Blachier, Francois
通讯作者：
Blachier, Francois
影响因子：
4.8
作者：
Biagi, E.;Zama, D.;Candela, M.
通讯作者：
Candela, M.