The coevolution of gene family trees
The coevolution of gene family trees
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DOI：
10.1016/s0168-9525(96)80020-5
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发表时间：
1996-09-01
影响因子：
11.4
通讯作者：
Fryxell, KJ
中科院分区：
文献类型：
--
作者：
Fryxell, KJ
基因复制突变体在细菌、噬菌体、昆虫和哺乳动物细胞中以高速率自发产生，并且通常是活的。因此，基因复制和分化的进化过程中的限速步骤可能不是基因复制本身。相反，很可能只有一小部分复制的基因被保留下来，并能够分化成新的特异性。此外，基因重复和功能相关的基因家族往往表现出相似的分歧日期，功能特异性，和系统发育树拓扑结构。这些相关性表明，功能相关的基因家族的家谱共同进化，因为功能互补的基因复制和分歧事件往往被自然选择保留。
Gene duplication mutants arise spontaneously at a high rate in bacteria, bacteriophages, insects and mammalian cells, and are generally viable. Thus, the rate-limiting step in the evolutionary process of gene duplication and divergence was probably not gene duplication per se. Rather, it is likely that only a small fraction of all duplicated genes were retained, and were able to diverge into new specificities. Furthermore, gene duplications and functionally related gene families often show similarities in divergence dates, functional specificities, and phylogenetic tree topologies. These correlations suggest that the family trees of functionally related gene families coevolved because functionally complementary gene duplication and divergence events tended to be retained by natural selection.