Self-synchronizing pairwise production of monodisperse droplets by microfluidic step emulsification
Self-synchronizing pairwise production of monodisperse droplets by microfluidic step emulsification
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DOI：
10.1063/1.3050461
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发表时间：
2008-12-22
影响因子：
4
通讯作者：
Seemann, Ralf
中科院分区：
文献类型：
--
作者：
Chokkalingam, Venkatachalam;Herminghaus, Stephan;Seemann, Ralf
具有优异单分散性的液滴对的原位生成对于基于液滴的微流控芯片中的定量（生物）化学反应是必不可少的。在本文中，我们证明了同时自同步生产的液滴与两个不同的内容，逐步乳化。同步是通过两个相连的生产单元的压力串扰实现的，同时保留一步乳化单元的所有相关特性。可以实现成对和三重液滴。虽然两种液滴类型的液滴体积可能相差高达2倍，但每种类型的优异单分散性得以保留。
The in situ generation of pairs of droplets with excellent monodispersity is essential for quantitative (bio-)chemical reactions in a droplet based microfluidic chip. In the present paper, we demonstrate the simultaneous self-synchronized production of droplets with two different contents by step emulsification. The synchronization is achieved by a pressure cross talk of two connected production units while retaining all relevant properties of a single-step-emulsification unit. Pairs and triplets of droplets can be achieved. While the drop volumes of the two droplet types may be different up to a factor of 2, the excellent monodispersity of each type is retained.