ASCENDING CENTRAL GUSTATORY PATHWAYS
ASCENDING CENTRAL GUSTATORY PATHWAYS
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DOI：
10.1002/cne.901500208
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发表时间：
1973-01-01
影响因子：
2.5
通讯作者：
LEONARD, CM
中科院分区：
文献类型：
--
作者：
NORGREN, R;LEONARD, CM
使用电生理-神经解剖学联合技术追踪了白化病大鼠的中枢味觉通路。延髓的味觉反应记录在孤核的区域，接受第七神经初级传入。从这些记录部位的病变中追踪到的纤维没有如预期的那样交叉进入内侧丘系，而是在进入脑桥时向吻侧行进，在同侧终止于结膜臂背侧和腹侧的小细胞区域。由于味觉反应可以记录在这个区域，它代表了一个以前未描述的二级“脑桥味觉区”。PTA的病变导致在背内侧被盖行进到丘脑的经典味觉核终止的双侧上行通路的变性。该通路中的其他纤维继续向吻侧延伸，分布于腹侧前脑的下丘脑、下丘脑背外侧和苍白球下灰质。哺乳动物的这些发现与Herrick（'05）在近四分之三个世纪前在鲤鱼中建立的发现相似，并证实了他的预测，即“在所有脊椎动物的外周和中央味觉路径之间[将发现]广泛的相似性”。
The central gustatory pathways of the albino rat have been traced using a combined electrophysiological‐neuroanatomical technique. Gustatory responses in the medulla were recorded in the region of the solitary nucleus which receives the seventh nerve primary afferents. Fibers traced from lesions of these recording sites did not cross as expected into the medial lemniscus, but instead travelled rostrally to terminate ipsilaterally in a small celled area dorsal and ventral to the brachium conjunctivum as it enters the pons. Since gustatory responses could be recorded in this region it represents a previously undescribed secondary “pontine taste area.” Lesions of PTA result in degeneration of a bilateral ascending pathway travelling in the dorsomedial tegmentum to terminate in the classical gustatory nuclei of the thalamus. Other fibers in this pathway continue rostrally and distribute in the subthalamus, dorsolateral hypothalamus and subpallidal gray in the ventral forebrain. These findings in a mammal resemble those established nearly three quarters of a century ago by Herrick ('05) in the carp, and confirm his prediction that “broad lines of similarity [would be found] between both the peripheral and central gustatory paths in all vertebrates”.