Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders
Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders
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DOI：
10.1176/appi.ajp.2007.07071145
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发表时间：
2008-06-01
影响因子：
17.7
通讯作者：
Blair, R. J. R.
中科院分区：
文献类型：
--
作者：
Marsh, Abigail A.;Finger, Elizabeth C.;Blair, R. J. R.
目的：大量研究表明，在具有冷酷无情特征的成年人的情绪面部表情处理中，杏仁核激活异常。然而，还没有研究调查具有破坏性行为和冷酷无情特征的青少年杏仁核对情绪面部表情的反应。此外，尽管冷酷无情感特征和注意力缺陷多动障碍 (ADHD) 的合并症很高，但没有研究试图区分儿科冷酷无情感特征和 ADHD 的神经相关性。 方法：参与者为 36 名儿童和青少年（10-17 岁）； 12 人具有冷酷无情的特征，并且有品行障碍或对立违抗障碍，12 人患有多动症，12 人是健康的对照对象。功能性核磁共振成像用于评估处理恐惧面部表情时杏仁核的激活模式。将冷酷无情感特征组的模式与多动症组和对照组进行比较。结果：在具有冷酷无情感特征的青少年中，相对于健康对照受试者和患有多动症的青少年，在处理恐惧表情时杏仁核激活减少，但处理中性或愤怒表情时则不然。功能连接分析表明，与具有冷酷无情特征的受试者和青少年相比，患有多动症的受试者和青少年的杏仁核和腹内侧前额叶皮层之间存在更大的相关性。冷酷无情感特征组的症状严重程度与杏仁核和腹内侧前额叶皮层之间的连接呈负相关。结论：这是第一项证明具有冷酷无情感特征的青少年杏仁核反应性降低的研究。这些发现支持这样的观点，即冷酷无情的人格特征与杏仁核对基于痛苦的社交线索的反应减弱有关。
Objective: Extensive work implicates abnormal amygdala activation in emotional facial expression processing in adults with callous-unemotional traits. However, no research has examined amygdala response to emotional facial expressions in adolescents with disruptive behavior and callous-unemotional traits. Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of pediatric callous-unemotional traits and ADHD.Method: Participants were 36 children and adolescents (ages 10-17 years); 12 had callous-unemotional traits and either conduct disorder or oppositional defiant disorder, 12 had ADHD, and 12 were healthy comparison subjects. Functional MRI was used to assess amygdala activation patterns during processing of fearful facial expressions. Patterns in the callous-unemotional traits group were compared with those in the ADHD and comparison groups.Results: In youths with callous-unemotional traits, amygdala activation was reduced relative to healthy comparison subjects and youths with ADHD while processing fearful expressions, but not neutral or angry expressions. Functional connectivity analyses demonstrated greater correlations between the amygdala and the ventromedial prefrontal cortex in comparison subjects and youths with ADHD relative to those with callous-unemotional traits. Symptom severity in the callous-unemotional traits groups was negatively correlated with connectivity between amygdala and ventromedial prefrontal cortex.Conclusions: This is the first study to demonstrate reduced amygdala responsiveness in youths with callous-unemotional traits. These findings support the contention that callous and unemotional personality traits are associated with reduced amygdala response to distress-based social cues.