Inhibition of collagen accumulation in fibrotic processes: review of pharmacologic agents and new approaches with amino acids and their analogues.
Inhibition of collagen accumulation in fibrotic processes: review of pharmacologic agents and new approaches with amino acids and their analogues.
复制标题
纤维化过程中胶原蛋白积累的抑制：药物制剂和氨基酸及其类似物新方法的回顾。
DOI：
10.1111/1523-1747.ep12545951
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Ryhänen,L
中科院分区：
文献类型：
--
作者：
Uitto,J;Tan,EM;Ryhänen,L
胶原蛋白的积累是多种纤维化过程的主要病理特征，包括进行性系统性硬化症、硬斑病、家族性皮肤胶原蛋白、胶原型结缔组织痣和疤痕疙瘩中的真皮纤维化。胶原蛋白生物化学的最新进展使我们能够确定胶原蛋白生物合成和降解的特定水平，在该水平下药物干预可以减少胶原蛋白沉积。在这篇综述中，我们正在讨论目前使用的一些治疗药物的作用机制。我们进一步介绍了一些涉及氨基酸及其类似物的新进展，这些进展可能为我们提供减少真皮纤维化过程中胶原蛋白过度积累的新方法。
Accumulation of collagen is the major pathologic feature in a variety of fibrotic processes, including dermal fibrosis in progressive systemic sclerosis, morphea, familial cutaneous collagenonia, connective tissue nevi of the collagen type and in keloids. Recent advances in the biochemistry of collagen have allowed us to define specific levels of collagen biosynthesis and degradation at which a pharmacologic intervention can lead to reduced collagen deposition. In this review, we are discussing the mechanisms of action by some of the therapeutic agents currently in use. We further present some new developments involving amino acids and their analogues which could potentially provide us with novel means to reduce the excessive accumulation of collagen in dermal fibrotic processes.