Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies
Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies
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DOI：
10.1093/rheumatology/kep252
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发表时间：
2009-10-01
期刊：
影响因子：
5.5
通讯作者：
Allanore, Yannick
中科院分区：
文献类型：
--
作者：
Meune, Christophe;Touze, Emmanuel;Allanore, Yannick
目标。已知 RA 与高心血管 (CV) 风险相关。纵向数据表明，在过去的几十年里，类风湿性关节炎的病程可能变得更加温和。因此，我们着手估计与 RA 相关的 CV 死亡率总体增加的幅度，并确定其在过去 50 年中是否有所下降。我们对 1960 年 1 月至 2008 年 11 月 MEDLINE 和 EMBASE 数据库中的文献进行了系统回顾和荟萃分析。所有报告 CV 死亡风险的队列研究均纳入其中。然后，我们计算了 CV 死亡率的汇总标准化死亡率 (SMR)，并使用元回归分析确定了它们随时间的演变。结果。分析了 17 项研究，总计 91916 名患者。总体合并 SMR 为 1.6（95% Cl 1.5, 1.8；I-2=93%；P(het)
Objectives. RA is known to be associated with a high cardiovascular (CV) risk. Longitudinal data suggest that RA disease course may have become milder over the past decades. Thus, we set out to estimate the magnitude of the overall increase in CV mortality associated with RA and to determine whether it has decreased over the past 50 years.Methods. We performed a systematic review and a meta-analysis of literature in MEDLINE and EMBASE databases from January 1960 to November 2008. All cohort studies reporting CV mortality risk were included. We then calculated pooled standardized mortality ratios (SMRs) of CV mortality, and determined their evolution with time using meta-regression analysis.Results. Seventeen studies were analysed, corresponding to a total of 91916 patients. The overall pooled SMR was 1.6 (95% Cl 1.5, 1.8; I-2=93%; P(het)