The ESCRT machinery: from the plasma membrane to endosomes and back again.
The ESCRT machinery: from the plasma membrane to endosomes and back again.
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DOI：
10.3109/10409238.2014.881777
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发表时间：
2014-05
影响因子：
6.5
通讯作者：
Audhya A
中科院分区：
文献类型：
--
作者：
Schuh AL;Audhya A
脂质双分子层的操纵和重组是多种细胞过程所必需的，从细胞器生物发生到细胞动力学脱落，通常涉及短暂的膜破坏。一组膜相关蛋白统称为运输所需的内体分选复合体（ESCRT）机制，与膜断裂步骤有关，该步骤将单个连续的双分子层转化为两个不同的双分子层，同时在整个过程中分离货物。ESCRT通路的组成部分包括5种不同的蛋白质复合物和一系列辅助因子，每种都具有独立的功能。本文综述了ESCRT蛋白促进货物封存和膜重塑的分子机制，并强调了它们在细胞稳态中的独特作用。
The manipulation and reorganization of lipid bilayers are required for diverse cellular processes, ranging from organelle biogenesis to cytokinetic abscission, and often involves transient membrane disruption. A set of membrane-associated proteins collectively known as the endosomal sorting complex required for transport (ESCRT) machinery has been implicated in membrane scission steps, which transform a single, continuous bilayer into two distinct bilayers, while simultaneously segregating cargo throughout the process. Components of the ESCRT pathway, which include 5 distinct protein complexes and an array of accessory factors, each serve discrete functions. This review focuses on the molecular mechanisms by which the ESCRT proteins facilitate cargo sequestration and membrane remodeling and highlights their unique roles in cellular homeostasis.
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DOI：
10.1083/jcb.200508166
发表时间：
2006-02-27
期刊：
The Journal of cell biology
影响因子：
--
作者：
Azmi I;Davies B;Dimaano C;Payne J;Eckert D;Babst M;Katzmann DJ
通讯作者：
Katzmann DJ
影响因子：
4.8
作者：
Bowers, K;Piper, SC;Luzio, JP
通讯作者：
Luzio, JP
影响因子：
11.4
作者：
Alam, SL;Sun, J;Sundquist, WI
通讯作者：
Sundquist, WI
影响因子：
5.7
作者：
Agromayor, Monica;Soler, Nicolas;Caballe, Anna;Kueck, Tonya;Freund, Stefan M.;Allen, Mark D.;Bycroft, Mark;Perisic, Olga;Ye, Yu;McDonald, Bethan;Scheel, Hartmut;Hofmann, Kay;Neil, Stuart J. D.;Martin-Serrano, Juan;Williams, Roger L.
通讯作者：
Williams, Roger L.
VPS27-HSE1和ESCRT-I复合物配合，以提高在内体处分类泛素化蛋白的效率。
影响因子：
7.8
作者：
Bilodeau, PS;Winistorfer, SC;Kearney, WR;Robertson, AD;Piper, RC
通讯作者：
Piper, RC