Perineural Invasion and Associated Pain Transmission in Pancreatic Cancer.
Perineural Invasion and Associated Pain Transmission in Pancreatic Cancer.
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胰腺癌的神经侵袭和相关的疼痛传递。
DOI：
10.3390/cancers13184594
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发表时间：
2021-09-13
期刊：
影响因子：
5.2
通讯作者：
Zou X
中科院分区：
文献类型：
--
作者：
Wang J;Chen Y;Li X;Zou X
神经浸润是一个复杂的过程，涉及肿瘤微环境中的一系列细胞和细胞外基质成分，特别是癌细胞和神经元之间的串扰。许多恶性肿瘤，包括胃癌、胆道肿瘤和胰腺癌，都有神经浸润。它在大约80-100%的胰腺癌患者中被确定，并与生存率低和生活质量下降相关。广泛的研究已经揭示了神经周围侵袭过程中微妙的分子调控机制，以及与胰腺癌相关疼痛的潜在因果关系。在此，我们将介绍胰腺癌患者的神经侵犯的潜在机制及其与顽固性疼痛的可能关系。胰腺导管腺癌（PDAC）是发生率最高的神经浸润（PNI）肿瘤之一，其预后往往较差。侵袭性肿瘤细胞侵入神经，引起神经源性炎症;肿瘤微环境也诱导神经经历一系列结构和功能重编程。反过来，神经元和周围的神经胶质细胞通过自分泌和/或旁分泌信号传导促进胰腺癌的发展。此外，PDAC患者的痛觉过敏意味着外周和中枢神经系统中疼痛传递的改变。目前，对这一问题的研究相对有限。本文将从近年来肿瘤与神经系统相互作用的机制及其与疼痛的可能关系几个方面进行综述。
Perineural invasion is a complicated process involving a series of cells and extracellular matrix components in the tumor microenvironment, particularly the crosstalk between cancer cells and neurons. Perineural invasion occurs in many malignant tumors, including gastric carcinoma, biliary tract tumor and pancreatic cancer. It is identified in approximately 80–100% of pancreatic cancer patients and is correlated with poor survival and decreased quality of life. Extensive studies have revealed the subtle molecule regulatory mechanisms during perineural invasion, as well as the potential causal link with pancreatic cancer-associated pain. Here, we introduce the underlying mechanism of perineural invasion and its possible relationship with the intractable pain in pancreatic cancer patients. Pancreatic ductal adenocarcinoma (PDAC) is one of the cancers with the highest incidence of perineural invasion (PNI), which often indicates a poor prognosis. Aggressive tumor cells invade nerves, causing neurogenic inflammation; the tumor microenvironment also induces nerves to undergo a series of structural and functional reprogramming. In turn, neurons and the surrounding glial cells promote the development of pancreatic cancer through autocrine and/or paracrine signaling. In addition, hyperalgesia in PDAC patients implies alterations of pain transmission in the peripheral and central nervous systems. Currently, the studies on this topic are relatively limited. This review will elaborate on the mechanisms of tumor–neural interactions and its possible relationship with pain from several aspects that have been focused on in recent years.
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通讯作者：
Grimmond, Sean M.