18F-FAMT-PET Is Useful for the Diagnosis of Lymph Node Metastasis in Operable Esophageal Squamous Cell Carcinoma
18F-FAMT-PET Is Useful for the Diagnosis of Lymph Node Metastasis in Operable Esophageal Squamous Cell Carcinoma
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DOI：
10.1245/s10434-010-1177-y
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发表时间：
2010-12-01
影响因子：
3.7
通讯作者：
Kuwano, Hiroyuki
中科院分区：
文献类型：
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作者：
Sohda, Makoto;Kato, Hiroyuki;Kuwano, Hiroyuki
近年来，正电子发射断层扫描（PET）在某些肿瘤中的作用和潜在用途已得到广泛研究。F-18-FAMT（L-[3-F-18]-α-甲基酪氨酸）是PET的氨基酸示踪剂。本研究旨在探讨与F-18-FDG相比，F-18-FAMT PET/CT是否能为食管鳞状细胞癌术前诊断提供更多信息使用F-18-FAMT和F-18-FAMT的PET/CT研究对21例经病理证实的食管鳞状细胞癌患者术前进行FDG检查，F-18-FAMT-PET对原发性食管癌的敏感性为76.2%，而F-18-FDG-PET的敏感性为90.5%（P = 0.214）。F-18-FAMT摄取与肿瘤浸润深度（P = 0.005）、淋巴结转移（P = 0.045）、分期（P = 0.031）和淋巴结转移（P = 0.029）相关。在单个淋巴结组的评估中，F-18-FAMT-PET显示出18.2%的灵敏度、100%的特异性、71.9%的准确性、100%的阳性预测值和70.0%的阴性预测值，而F-18 FDG-PET分别为24.2%、93.7%、69.8%、66.6%和70.2%。CT的敏感性为39.4%，特异性为85.7%，准确性为69.8%，阳性预测值为59.1%，阴性预测值为73.0%。F-18-FAMT-PET的特异性显著高于F-18-FDG-PET（P = 0.042）和CT（P = 0.002）。与F-18-FDG-PET相比，F-18-FAMT-PET没有任何假阳性结果。我们的研究结果表明，在F-18-FDG-PET和CT中增加F-18-FAMT-PET将允许更精确的食管癌分期。
The role and potential usefulness of positron emission tomography (PET) scanning in certain tumors has been widely investigated in recent years. F-18-FAMT (L-[3-F-18]-alpha-methyltyrosine) is an amino acid tracer for PET. This study investigated whether PET/CT with F-18-FAMT provides additional information for preoperative diagnostic workup of esophageal squamous cell carcinoma compared with that obtained by F-18-FDG (fluorodeoxyglucose) PET or CT.PET/CT studies with F-18-FAMT and F-18-FDG were performed as a part of the preoperative workup in 21 patients with histologically confirmed esophageal squamous cell carcinoma.For the detection of primary esophageal cancer, F-18-FAMT-PET exhibited a sensitivity of 76.2%, whereas the sensitivity for F-18-FDG-PET was 90.5% (P = 0.214). F-18-FAMT uptake in primary tumors showed significant correlation with depth of invasion (P = 0.005), lymph node metastasis (P = 0.045), stage (P = 0.031), and lymphatic invasion (P = 0.029). In the evaluation of individual lymph node groups, F-18-FAMT-PET exhibited 18.2% sensitivity, 100% specificity, 71.9% accuracy, 100% positive predictive value, and 70.0% negative predictive value, compared with 24.2%, 93.7%, 69.8%, 66.6%, and 70.2%, respectively, for F-18 FDG-PET. CT exhibited 39.4% sensitivity, 85.7% specificity, 69.8% accuracy, 59.1% positive predictive value, and 73.0% negative predictive value. The specificity of F-18-FAMT-PET is significantly higher than that of F-18-FDG-PET (P = 0.042) and CT (P = 0.002). F-18-FAMT-PET did not have any false-positive findings compared to those with F-18-FDG-PET.Our findings suggest that the addition of F-18-FAMT-PET to F-18-FDG-PET and CT would permit more precise staging of esophageal cancer.