Growth of the ferret tracheobronchial tree.
Growth of the ferret tracheobronchial tree.
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DOI：
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发表时间：
1990-03
期刊：
影响因子：
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通讯作者：
M. Oldham;R. Phalen;R. Huxtable
中科院分区：
文献类型：
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作者：
M. Oldham;R. Phalen;R. Huxtable
由于雪貂被越来越多地用于吸入毒理学和肺生理学研究，因此有必要更好地了解其气管支气管树的气道结构。以前发表的信息不包括尺寸的支气管和细支气管在成年或成长的雪貂。用于计算吸入颗粒沉积模式的感兴趣的气道结构包括每一代中的气道长度、直径和分支角度。这些尺寸的测量获得了几个选定的气道路径上的复制铸件。在14小时、9.5天、16.5天和56天的四只雄性窝仔中原位制作铸型。这些数据表明，与人类肺部生长一样，给定年龄的体长是气道长度和直径的良好预测因子。气道分支角度在生长过程中似乎没有显著变化。进行了充分的测量，以提供该物种典型气管支气管通路的尺寸。该通路始于气管，止于终末细支气管。形态测量数据不足以确定出生后气管支气管代数是否增加或减少。
Because the ferret is being used increasingly in inhalation toxicology and lung physiology studies, it is necessary to better understand the airway structure of its tracheobronchial tree. Previously published information does not include dimensions of bronchi and bronchioles in either adult or growing ferrets. The airway structure of interest for calculating inhaled particle deposition patterns includes airway lengths, diameters and branching angles in each generation. Measurements of these dimensions were obtained for several selected airway paths on replica casts. Casts were made in-situ in four male litter mates age 14 hours, 9.5 days, 16.5 days and 56 days. These data demonstrate, that as with human lung growth, body length at a given age is a good predictor of airway lengths and diameters. Airway branch angles do not appear to change significantly during growth. Sufficient measurements were made to provide dimensions of a typical tracheobronchial pathway for this species. This pathway begins with the trachea and ends at the terminal bronchiole. The morphometric data were not sufficient to determine whether or not the number of tracheobronchial generations increase or decrease postnatally.