Selective functional integration between anterior temporal and distinct fronto-mesolimbic regions during guilt and indignation.
Selective functional integration between anterior temporal and distinct fronto-mesolimbic regions during guilt and indignation.
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DOI：
10.1016/j.neuroimage.2010.05.038
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发表时间：
2010-10-01
期刊：
影响因子：
5.7
通讯作者：
Zahn, Roland
中科院分区：
文献类型：
--
作者：
Green, Sophie;Ralph, Matthew A. Lambon;Moll, Jorge;Stamatakis, Emmanuel A.;Grafman, Jordan;Zahn, Roland
关键词：
有人假设，不同的道德情感，如内疚和愤怒的经验是由激活颞叶和额叶-中脑边缘区，这些区域之间的功能整合是必要的这些道德情感的差异化的经验。最近的一项功能磁共振成像研究显示，无论道德情感（内疚或愤怒）的背景如何，右侧上级前颞叶（ATL）都会被激活。这一区域一直与上下文无关的概念社会知识，使我们能够细粒度区分社会行为的质量（如“关键”和“挑剔”）。这些知识是对社会行为进行情感评估所必需的。与ATL的情境独立激活相反，内疚和愤怒在不同的额中边缘区域内存在情境依赖性激活。然而，这是未知的功能整合是否发生在这些地区之间，以及是否区域模式的整合是不同的经验，不同的道德情操。在这里，我们使用功能磁共振成像和心理生理学的相互作用分析，功能整合的既定措施来调查这个问题。我们发现，在内疚的经验，右上级ATL和膝下扣带区域之间的选择性功能整合和右上级ATL和外侧眶额皮质之间的愤怒。我们的数据提供了第一个证据的功能整合的概念性社会知识的表征在右上级ATL与表征不同的感觉背景中的额-中边缘区。我们推测，这种功能架构允许在健康个体的道德情感的概念上有区别的经验。
It has been hypothesized that the experience of different moral sentiments such as guilt and indignation is underpinned by activation in temporal and fronto-mesolimbic regions and that functional integration between these regions is necessary for the differentiated experience of these moral sentiments. A recent fMRI study revealed that the right superior anterior temporal lobe (ATL) was activated irrespective of the context of moral feelings (guilt or indignation). This region has been associated with context-independent conceptual social knowledge which allows us to make fine-grained differentiations between qualities of social behaviours (e.g. “critical” and “faultfinding”). This knowledge is required to make emotional evaluations of social behaviour. In contrast to the context-independent activation of the ATL, there were context-dependent activations within different fronto-mesolimbic regions for guilt and indignation. However, it is unknown whether functional integration occurs between these regions and whether regional patterns of integration are distinctive for the experience of different moral sentiments. Here, we used fMRI and psychophysiological interaction analysis, an established measure of functional integration to investigate this issue. We found selective functional integration between the right superior ATL and a subgenual cingulate region during the experience of guilt and between the right superior ATL and the lateral orbitofrontal cortex for indignation. Our data provide the first evidence for functional integration of conceptual social knowledge representations in the right superior ATL with representations of different feeling contexts in fronto-mesolimbic regions. We speculate that this functional architecture allows for the conceptually differentiated experience of moral sentiments in healthy individuals.
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影响因子：
11
作者：
Bozeat, S;Gregory, CA;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
5.7
作者：
Heekeren, HR;Wartenburger, I;Villringer, A
通讯作者：
Villringer, A
影响因子：
3.3
作者：
Drevets, Wayne C.;Savitz, Jonathan
通讯作者：
Savitz, Jonathan
DOI：
10.1073/pnas.0705654104
发表时间：
2007-12-18
影响因子：
11.1
作者：
Kriegeskorte, Nikolaus;Formisano, Elia;Goebel, Rainer
通讯作者：
Goebel, Rainer
影响因子：
10.5
作者：
BERRIOS, GE;BULBENA, A;MITCHELL, SL
通讯作者：
MITCHELL, SL