State anxiety modulates the effect of emotion cues on visual temporal sensitivity in autism spectrum disorder
State anxiety modulates the effect of emotion cues on visual temporal sensitivity in autism spectrum disorder
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DOI：
10.1111/ejn.15311
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发表时间：
2021-06-07
影响因子：
3.4
通讯作者：
Ide, Masakazu
中科院分区：
文献类型：
--
作者：
Chakrabarty, Mrinmoy;Atsumi, Takeshi;Ide, Masakazu
在自闭症谱系障碍(ASD)中，刺激输入的非典型加工在一系列感觉模式中被广泛报道。众所周知，感觉处理受到生理唤醒和焦虑等身体内部状态的影响。据报道，相当大比例的自闭症患者患有与调节失调的觉醒有关的共病焦虑障碍，我们调查了自闭症患者(n=20)与典型发育个体(TD，n=21)的匹配组相比，面部情绪唤醒线索是否影响视觉感觉敏感性(以时间分辨率为指标)。我们进一步询问，视觉敏感度的情绪线索变化是否与状态和特质焦虑的个体差异有关。参与者报告了在视觉时间顺序判断任务(v-TOJ)中，连续两次高斯斑点闪烁中的第二次的偏侧性，这需要更高级别的视觉处理。关键操作是在与任务相关的闪现之前的意想不到的时间点短暂地呈现与任务无关的面孔情绪线索。与中性情绪信号相比，厌恶情绪信号显著提高了ASD患者的视觉时间分辨率。在自闭症患者中，个体状态焦虑得分与情绪线索的时间分辨率变化(厌恶与中性)显示出良好的相关趋势，但没有统计学意义。这两种影响在TD中都不存在。结果表明，个体状态焦虑水平可能调节情绪对自闭症患者视觉时间敏感性的影响。这些发现支持一种微妙的方法来理解ASD的不同感觉特征，通过考虑个体对环境情感信息的反应和焦虑的严重程度的相互作用。
Atypical processing of stimulus inputs across a range of sensory modalities in autism spectrum disorder (ASD) is widely reported. Sensory processing is known to be influenced by bodily internal states such as physiological arousal and anxiety. As a sizeable proportion of ASD reportedly have co-morbid anxiety disorders that are linked with dysregulated arousal, we investigated if face emotion arousal cues influenced visual sensory sensitivity (indexed by temporal resolution) in ASD (n = 20) compared to a matched group of typically developed individuals (TD, n = 21). We asked further if emotion-cued changes in visual sensitivity were associated with individual differences in state and trait anxiety. Participants reported the laterality of the second of two consecutive Gaussian-blob flashes in a visual temporal order judgment task (v-TOJ), demanding higher-level visual processing. The key manipulation was presenting a task-irrelevant face emotion cue briefly at unexpected time points preceding the task-relevant flashes. Disgust vs. Neutral emotion signals significantly enhanced the visual temporal resolution in ASD. Individual state-anxiety scores showed a fair correlative trend with the emotion-cued changes in temporal resolution (Disgust versus Neutral) in ASD but missed statistical significance. Both these effects were absent in TD. The results show that individual state-anxiety levels likely modulate the effect of emotions on visual temporal sensitivity in ASD. The findings support a nuanced approach to understand the disparate sensory features in ASD, by factoring in the interplay of the individual reactivity to environmental affective information and the severity of anxiety.