Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. A clinicopathologic study of 245 cases.
Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. A clinicopathologic study of 245 cases.
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甲状腺恶性淋巴瘤和其他淋巴增殖性疾病。
DOI：
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发表时间：
1980
影响因子：
3.5
通讯作者：
J. Oertel
中科院分区：
文献类型：
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作者：
J. Compagno;J. Oertel
本文对245例恶性淋巴瘤和其他累及甲状腺的淋巴增生性疾病进行了研究。患者，主要是老年妇女，通常表现为颈部肿块迅速增大，通常有气管或喉部受压的症状。甲状腺的放射性同位素扫描通常显示“冷”或“冷”的过程，气管偏曲(如胸片所见)是常见的。淋巴瘤和相关过程几乎总是与潜在的淋巴细胞性甲状腺炎有关。平均随访时间为45个月，随访率为96%。预后不良与肿瘤细胞向腺体包膜外扩散、肿瘤坏死、血管壁浸润、弥漫构筑、颈淋巴结侵犯有关，有无颈外病变。完全由浆细胞组成的肿瘤几乎没有全身性扩展的倾向，而那些有一定浆细胞样分化的淋巴瘤也显示出更好的预后。
Two hundred and forty-five cases of malignant lymphoma and other lymphoproliferative disorders involving the thyroid gland have been studied. The patients, predominantly elderly women, usually presented with a rapidly enlarging mass in the neck, often with symptoms of tracheal or laryngeal compression. Radioisotopic scanning of the thyroid usually demonstrated a "cold" or "cool" process, and tracheal deviation (as seen by chest roentgenogram) was common. Lymphoma and related processes were nearly always associated with an underlying lymphocytic thyroiditis. The mean length of follow-up was 45 months, and follow-up was obtained in 96% of the cases. An unfavorable prognosis was related to extension of tumor cells outside the capsule of the gland, necrosis of the tumor, blood vessel wall infiltration, diffuse architectural pattern, and cervical lymph node involvement, with or without disease outside the neck. Tumors composed entirely of plasma cells demonstrated little if any tendency toward systemic extension, and those lymphomas with some plasmacytoid differentiation also displayed a more favorable prognosis.