Is the time interval between HCG administration and oocyte retrieval associated with oocyte retrieval rate?
Is the time interval between HCG administration and oocyte retrieval associated with oocyte retrieval rate?
复制标题
DOI：
10.1016/j.rbmo.2015.08.005
复制
发表时间：
2015-11-01
影响因子：
4
通讯作者：
Tarlatzis, Basil
中科院分区：
文献类型：
--
作者：
Bosdou, Julia K.;Kolibianakis, Efstratios M.;Tarlatzis, Basil
本研究旨在探讨促性腺激素和促性腺激素释放激素(GnRH)拮抗剂在体外受精(IVF)中应用促性腺激素和促性腺激素释放激素(GnRH)拮抗剂进行卵巢促排卵是否会影响促性腺激素和促性腺激素释放激素(GnRH)拮抗剂促排卵效果。156例排卵正常的妇女被随机分成两组，分别在注射hCG后36h(n=78)和38h(n=78)取卵。取卵率定义为注射HCG当天获得的卵丘-卵母细胞复合体(COC)数/卵泡数=11 mm。在基线特征方面，两组之间没有观察到显著差异。两组取卵率差异无统计学意义(中位数差值：+1.2%，95%CI：-4.5~+12.1)。取卵丘-卵母细胞复合体(COCs)的中位数分别为5.5(5.0-7.0)和6.0(5.0-6.2)，受精率分别为57.7%(50.0-66.7)和50.0%(44.8-65.5)，差异无统计学意义。两组间的活产率相似(分别为20.5%和16.7%，RD：+3.8%，95%CI：-8.5至+16.1)。将人绒毛膜促性腺激素给药至取卵间隔时间从36h延长至38h，不影响取卵率。(C)2015年生殖健康有限公司。爱思唯尔有限公司出版。版权所有。
The aim of this study was to evaluate whether prolongation of the time interval between HCG administration and oocyte retrieval, from 36 h to 38 h, affects oocyte retrieval rate in women undergoing ovarian stimulation with gonadotrophins and GnRH antagonists for IVF. One hundred and fifty-six normo-ovulatory women were randomized to have oocyte retrieval performed 36 h (n = 78) or 38 h (n = 78) following HCG administration. Oocyte retrieval rate was defined as number of cumulus-oocyte-complex (COC) retrieved/ follicle >= 11 mm present on day of HCG administration. No significant differences were observed between the groups regarding baseline characteristics. Moreover, no significant difference was observed between the groups regarding oocyte retrieval rate (difference: +1.2%, 95% CI for difference between medians: -4.5 to +12.1). The median (95% CI for the median) was not significantly different between the groups regarding number of cumulus-oocyte-complexes (COCs) retrieved: 5.5 (5.0-7.0) versus 6.0 (5.0-6.2), respectively, and fertilization rates: 57.7% (50.0-66.7) versus 50.0% (44.8-65.5), respectively. Live birth rates were similar between the groups (20.5% versus 16.7%, RD: +3.8%, 95% CI: -8.5 to +16.1, respectively). Prolongation of time interval between HCG administration and oocyte retrieval from 36 h to 38 h does not affect oocyte retrieval rate. (C) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.